| Identification | More | [Name]
L-M-TYROSINE | [CAS]
587-33-7 | [Synonyms]
3-HYDROXY-L-PHENYLALANINE
H-M-TYR-OH
H-S-META-TYR-OH
L-3-HYDROXY-PHENYLALANINE
L-META-TYROSINE
L-M-TYR
L-M-TYROSINE
META-TYROSINE
(S)-2-AMINO-3-(3-HYDROXY-PHENYL)-PROPIONIC ACID
3-(m-Hydroxyphenyl)alanine
3-Hydroxyphenylalanine
m-L-Tyrosine
L-Phe(3-OH)-OH
(S)-3-(3-Hydroxyphenyl)-2-aminopropionic acid
m-Hydroxy-L-phenylalanine | [Molecular Formula]
C9H11NO3 | [MDL Number]
MFCD00063059 | [Molecular Weight]
181.19 | [MOL File]
587-33-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
260-270°C | [alpha ]
D22 -14.5° (70% ethanol); D22 +8.9° (70% ethanol, 2N HCl) | [Boiling point ]
387.2±32.0 °C(Predicted) | [density ]
1.333±0.06 g/cm3(Predicted) | [storage temp. ]
Store at RT. | [solubility ]
Soluble in dimethyl sulfoxide, dilute acid. | [form ]
Solid | [pka]
2.20±0.10(Predicted) | [color ]
White to Pale Beige | [Water Solubility ]
2mg/mL, clear (0.1N HCl) | [Usage]
It is an unnatural amino acid ; shown application in the treatment of Parkinson disease, Alzheimer disease, artritis | [CAS DataBase Reference]
587-33-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [HS Code ]
2922500090 |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Beige Solid | [Uses]
It is an unnatural amino acid ; shown application in the treatment of Parkinson disease, Alzheimer disease, artritis | [Uses]
It is an unnatural amino acid ; shown application in the treatment of Parkinson’s disease, Alzheimer’s disease, artritis. | [Definition]
ChEBI: L-m-tyrosine is a hydroxyphenylalanine that is L-phenylalanine with a substituent hydroxy group at position 3. It has a role as a plant metabolite. It is a hydroxyphenylalanine, a L-phenylalanine derivative, a non-proteinogenic L-alpha-amino acid and a member of phenols. It is a tautomer of a L-m-tyrosine zwitterion. | [Biological Activity]
L-Meta-tyrosine is metabolite of L-Phenylalanine generated within the living organism by hydroxyl free radical. It is a marker of oxidative stress. Circulating L-Meta-tyrosine cold be incorporated into protein through the binding to the tRNAPhe. In plants L-Meta-tyrosine (m-Tyr) is also synthesized enzymatically and has been shown to act as a natural herbicide. It inhibits the growth of plants. L-Meta-tyrosine is a potent and selective competitive inhibitor of Enterobacteriaceae (CitrobacterProteusErwinia) tyrosine phenol-lyase th at exhibits a renoprotective effect in diabetic mice. L-Meta-tyrosine decreases plasma phenyl sulfate and indoxyl sulfate levels and reduces albuminuria in diabetic mice models. AlsoL-Meta-tyrosine inhibits bacterial tryptophan indole-lyase. It does not alter composition of microbiota in renal failure mice model. | [in vivo]
L-m-tyrosine (150 mg/kg; i.p.; single injection) reduces dopamine, norepinephrine and serotonin levels in the brain to approximately 50% of control values (at 60-90 min after injection) in male Sprague-Dawley rats[3].
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