| Identification | More | [Name]
(S)-2-Methyl-pyrrolidine | [CAS]
59335-84-1 | [Synonyms]
D-2-METHYLPYRROLIDINE
METHYLPYRROLIDINE(S-2-)
(S)-(+)-2-METHYLPYRROLIDINE
(S)-2-METHYL-PYRROLIDINE
(2S)-2-Methylpyrrolidine
2-(S)-METHYLPYRROLIDINE | [Molecular Formula]
C5H11N | [MDL Number]
MFCD07779425 | [Molecular Weight]
85.15 | [MOL File]
59335-84-1.mol |
| Chemical Properties | Back Directory | [Boiling point ]
97-99 °C(lit.) | [density ]
0.842 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.4354
| [Fp ]
45 °F
| [storage temp. ]
2-8°C | [pka]
10.93±0.10(Predicted) | [Appearance]
Colorless to light yellow Liquid | [Optical Rotation]
[α]20/D +19°, c = 5 in methanol | [InChI]
1S/C5H11N/c1-5-3-2-4-6-5/h5-6H,2-4H2,1H3/t5-/m0/s1 | [InChIKey]
RGHPCLZJAFCTIK-YFKPBYRVSA-N | [SMILES]
C[C@H]1CCCN1 | [CAS DataBase Reference]
59335-84-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
F,C | [Risk Statements ]
R11:Highly Flammable.
R22:Harmful if swallowed.
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2924 3/PG 2
| [WGK Germany ]
2
| [Hazard Note ]
Corrosive/Highly Flammable | [PackingGroup ]
Ⅱ | [HS Code ]
2933998090 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Acute Tox. 4 Oral
Flam. Liq. 2
Skin Corr. 1B |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of 2-methylpyrrolidine from 2-methylpyrroline was as follows: whole-cell biotransformation reactions were carried out at 30 °C in a shaker at 1000 rpm in a sodium phosphate buffer (100 mM, pH 7.0). Freshly harvested resting cells of E. coli BL21(DE3) expressing IRED with a final OD600nm value of 90 were used.The reaction mixture contained 2.5 or 5 mM of imine substrate and 50 mM of glucose as co-substrate. | [References]
[1] Organic and Biomolecular Chemistry, 2010, vol. 8, # 20, p. 4533 - 4535
[2] Bioscience, Biotechnology and Biochemistry, 2011, vol. 75, # 9, p. 1778 - 1782
[3] ChemBioChem, 2013, vol. 14, # 11, p. 1372 - 1379
[4] ChemCatChem, 2015, vol. 7, # 4, p. 579 - 583
[5] Journal of Molecular Catalysis B: Enzymatic, 2014, vol. 110, p. 126 - 132 |
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