| Identification | Back Directory | [Name]
T-cadinol | [CAS]
5937-11-1 | [Synonyms]
T-cadinol
Cedrelanol
10-Epicadinol
10-epi-α-Cadinol
(1S)-1,2,3,4,4aβ,7,8,8aα-Octahydro-1,6-dimethyl-4β-isopropyl-1-naphthol
(1S)-1,2,3,4,4aβ,7,8,8aα-Octahydro-1,6-dimethyl-4β-isopropylnaphthalen-1β-ol
1-Naphthalenol, 1,2,3,4,4a,7,8,8a-octahydro-1,6-dimethyl-4-(1-methylethyl)-, (1S,4S,4aR,8aR)- | [Molecular Formula]
C15H26O | [MOL File]
5937-11-1.mol | [Molecular Weight]
222.37 |
| Chemical Properties | Back Directory | [Melting point ]
139-140 °C | [Boiling point ]
303.4±31.0 °C(Predicted) | [density ]
0.937±0.06 g/cm3(Predicted) | [pka]
15.05±0.60(Predicted) | [Odor]
at 100.00 %. pure has no odor but mixtures have balsam earthy | [Odor Type]
balsamic | [LogP]
4.899 (est) |
| Hazard Information | Back Directory | [Uses]
T-Cadinol is a sesquiterpene isolated from C. sylvestris that exhibits anti-Trypanosoma cruzi activity, with IC50 values of 18.2 μM and 15.8 μM against trypomastigote and amastigote forms, respectively. T-Cadinol can induce mitochondrial damage in parasites, leading to membrane hyperpolarization and decreased levels of reactive oxygen species. T-Cadinol can be used for the research of Chagas disease[1]. | [Definition]
ChEBI:Tau-cadinol is a cadinane sesquiterpenoid that is cadin-4-ene carrying a hydroxy substituent at position 10. It has a role as a volatile oil component and a plant metabolite. It is a cadinane sesquiterpenoid, a carbobicyclic compound, a tertiary alcohol and a member of octahydronaphthalenes. | [References]
[1] Dos Santos AL, et al. (-)-T-Cadinol-a Sesquiterpene Isolated From Casearia sylvestris (Salicaceae)-Displayed In Vitro Activity and Causes Hyperpolarization of the Membrane Potential of Trypanosoma cruzi [published correction appears in Front Pharmacol. 2022 Mar 14;13:865432]. Front Pharmacol. 2021;12:734127. Published 2021 Nov 3. DOI:10.3389/fphar.2021.734127 |
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