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OADS is an inhibitor of ClC-ec1 with low micromolar affinity. OADS has no specific effect on a CLC channel (ClC-1). | [Uses]
OADS is a Chloride channel antiporter (ClC-ec1) inhibitor (IC50: 29 μM). OADS specifically inhibits the ClC-ec1 antiporter but not the ClC-1 channel. OADS can be used for research of osteoporosis and neurodegenerative and cardiovascular diseases[1]. | [References]
[1] Howery AE, et al. A designed inhibitor of a CLC antiporter blocks function through a unique binding mode. Chem Biol. 2012 Nov 21;19(11):1460-70. DOI:10.1016/j.chembiol.2012.09.017 |
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