| Identification | Back Directory | [Name]
Camostat | [CAS]
59721-28-7 | [Synonyms]
FOY 305
CAMOSTAT
Camostatum
Ccris 7219
FOY-305：Foipan
Unii-0fd207wkdu
Camostatum [inn-latin]
Camostat Monomethanesulfonate
59721-29-8 (Monomethanesulfonate)
Camostat (base and/or unspecified salts)
Dimethylcarbamoylmethyl 4-(4-guqnidinobenzoyloxy)phenylacetat
N，N-Dimethylcarbamoylmethyl-p(p-guanidinobenzoyloxy)phenylacetate
2-(Dimethylamino)-2-oxoethyl 4-(4-guanidinobenzoyloxy)phenylacetate
p-(p-Guanidinobenzoyloxy)phenylacetic acid=dimethylcarbamoylmethyl ester
4-Guanidinobenzoic acid-4-(dimethylcarbamoylmethoxycarbonylmethyl)phenyl ester
2-{4-[(4-carbaMiMidaMidophenyl)carbonyloxy]phenyl}-3-(diMethylcarbaMoyl)propanoate
4-Guanidinobenzoic acid 4-[[[(dimethylcarbamoyl)methoxy]carbonyl]methyl]phenyl ester
4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneaxetic acid 2-(dimethylamino)-oxoethyl ester
4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester
Benzeneacetic acid, 4-[[4-[(aMinoiMinoMethyl)aMino]benzoyl]oxy]-, 2-(diMethylaMino)-2-oxoethyl ester
4-[[4-[(aMinoiMinoMethyl)aMino]benzoyl]oxy]-, 2-(diMethylaMino)-2-oxoethyl ester, MonoMethanesulfonate | [Molecular Formula]
C20H22N4O5 | [MDL Number]
MFCD00867896 | [MOL File]
59721-28-7.mol | [Molecular Weight]
398.41 |
| Hazard Information | Back Directory | [Uses]
Camostat is an orally active trypsin inhibitor. Camostat can reduce pancreatic fibrosis induced by repeated administration of superoxide dismutase inhibitors in rats, and decrease the proliferation and activation of pancreatic stellate cells (PSCs)[1]. | [Definition]
ChEBI: Camostat is a benzoate ester resulting from the formal condensation of the carboxy group of 4-guanidinobenzoic acid with the hydroxy group of 2-(dimethylamino)-2-oxoethyl (4-hydroxyphenyl)acetate. It is a potent inhibitor of the human transmembrane protease serine 2 (TMPRSS2) and its mesylate salt is currently under investigation for its effectiveness in COVID-19 patients. It has a role as an anticoronaviral agent, a serine protease inhibitor, an antifibrinolytic drug, an anti-inflammatory agent, an antiviral agent, an antihypertensive agent and an antineoplastic agent. It is a tertiary carboxamide, a carboxylic ester, a diester, a member of guanidines and a benzoate ester. It is functionally related to a 4-guanidinobenzoic acid. It is a conjugate base of a camostat(1+). | [References]
[1] Emori Y, et al. Camostat, an oral trypsin inhibitor, reduces pancreatic fibrosis induced by repeated administration of a superoxide dismutase inhibitor in rats. J Gastroenterol Hepatol. 2005 Jun;20(6):895-9. DOI:10.1111/j.1440-1746.2005.03826.x |
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