| Identification | Back Directory | [Name]
ER-806201 | [CAS]
603987-35-5 | [Synonyms]
E6201
ER-806201
E 6201
(E6201)
1H-2-Benzoxacyclotetradecin-1,7(8H)-dione, 14-(ethylamino)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-3,4-dimethyl-, (3S,4R,5Z,8S,9S,11E)-
(2E,5S,6S,8Z,10R,11S)-17-(ethylamino)-5,6,15-trihydroxy-10,11-dimethyl-12-oxabicyclo[12.4.0]octadeca-1(18),2,8,14,16-pentaene-7,13-dione | [Molecular Formula]
C21H27NO6 | [MOL File]
603987-35-5.mol | [Molecular Weight]
389.44 |
| Hazard Information | Back Directory | [Uses]
E 6201 was discovered to have anti-inflammatory activities on immune cells and antihyperproliferative activities in keratinocytes. It is a potential anti-inflammatory drug. | [in vivo]
E6201 (30 mg/kg; administered via tail vein injection three times per week) inhibits TNBC xenograft tumor growth. E6201 strongly inhibits pERK and Ki-67 expression in xenograft tumor tissues[2]. | Animal Model: | Female Nod.Scid gamma mice (age 4 to 6 weeks old) bearing MDA-MB-231-LM2 xenograft tumors[2] | | Dosage: | 30 mg/kg | | Administration: | Administered via tail vein injection three times per week for 17 days | | Result: | Compared with mice treated with vehicle control, the E6201-treated mice showed 60% tumor growth suppression. |
| [IC 50]
MEK1: 5.2 nM (IC50) |
|
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|