| Identification | More | [Name]
6-HYDROXY-2-NAPHTHYL DISULFIDE | [CAS]
6088-51-3 | [Synonyms]
2,2'-DIHYDROXY-6,6'-DINAPHTHYL DISULFIDE
2,2'-DIHYDROXY-6,6'-DINAPHTHYLDISULPHIDE
6,6'-DIHYDROXY-2,2'-DINAPHTHYL DISULFIDE
6,6'-DITHIODI(2-NAPHTHOL)
6-HYDROXY-2-NAPHTHYL DISULFIDE
AKOS BBS-00001974
BIS(6-HYDROXY-2-NAPHTHYL) DISULFIDE
DDD
TIMTEC-BB SBB005947
6,6’-dithiobis-2-naphthaleno
6-HYDROXY-2-NAPHTHYL DISULFIDE 98%
6-HYDROXY-2-NAPHTHYLDISULPHIDE
6-HYDROXY-2-NAPHTHYL DISULFIDE 98+%
2,2μ-Dihydroxy-6,6μ-dinaphthyl disulfide, 6,6μ-Dihydroxy-2,2μ-dinaphthyl disulfide, 6,6μ-Dithiodi(2-naphthol), 6,6μ-Dithiodi-2-naphthol, Bis(2-hydroxy-6-naphthyl) disulfide, Bis(6-hydroxy-2-naphthyl) disulfide, DDD
6,6μ-Dihydroxy-2,2μ-dinaphthyl disulfide, 6-Hydroxy-2-naphthyl disulfide, Bis(6-hydroxy-2-naphthyl) disulfide
[6,6'-Dithiodinaphthalene]-2,2'-diol
6,6'-Dithiobis(2-naphthol)
Bis(6-hydroxy-2-naphtyl) persulfide
DDD0 | [EINECS(EC#)]
228-025-4 | [Molecular Formula]
C20H14O2S2 | [MDL Number]
MFCD00004083 | [Molecular Weight]
350.45 | [MOL File]
6088-51-3.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [TSCA ]
TSCA listed | [HS Code ]
2908990090 |
| Hazard Information | Back Directory | [Description]
DDD, 1,1-dichloro-2,2-bis-(4-chlorophenyl) ethane, also known as TDE, is a
metabolite of DDT, which found use in agriculture. As with DDT, the p,p -isomer is insecticidal and the o,p -isomer is an impurity. | [Uses]
For determination of protein-bound sulfhydryl groups. | [IC 50]
PAK1 | [Purification Methods]
It crystallises as leaflets from AcOH and is slightly soluble in EtOH, and AcOH, but is soluble in *C6H6 and in alkalis to give a yellow solution. [Zincke & Dereser Chem Ber 51 352 1918.] The acetoxy derivative has m 198-200o (from AcOH or dioxane/MeOH), and the diacetyl derivative has m 167-168o (from AcOH). A small amount of impure disulfide can be purified by dissolving it in a small volume of Me2CO and adding a large volume of toluene, filter rapidly and concentrate to one-third of its volume. The hot toluene solution is filtered rapidly from any tarry residue, and crystals separate on cooling. Recrystallisation from hot acetic acid gives crystals with m 220-223o [Barrett & Seligman Science 116 323 1952]. [Beilstein 6 I 481.] | [Toxicity evaluation]
Animal Studies. DDD is less acutely toxic
than DDT (29), with an oral LD50 of 3400 to 4000 mg/kg in
the rat and a dermal LD50 ca. 1200 mg/kg in the rabbit. In a
2-year chronic dietary study in the rat, a LOEL of 100 ppm
(5 mg/kg/day) was quoted for tissue damage, similar to that
produced by DDT.
Human Studies. Most of the studies conducted in
humans have used the o,p -isomer of DDD. This has been
used as a drug, with medical and veterinary uses, for the
treatment of Cushing’s syndrome and adrenal carcinoma,
under the generic name of mitotane. After oral ingestion,
o,p’-DDD binds to lung and adrenal tissue. Its toxicity to the
adrenal appears to be species-dependent, however, causing
gross atrophy in the dog and reducing corticosteroid
production without pathological effects in other mammals,
including humans. |
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