| Identification | More | [Name]
2-Hydroxycaprylic acid | [CAS]
617-73-2 | [Synonyms]
2-HYDROXYCAPRYLIC ACID
2-HYDROXY-N-CAPRYLIC ACID
2-HYDROXY-N-OCTANOIC ACID
(+/-)-2-HYDROXYOCTANOIC ACID
2-HYDROXYOCTANOIC ACID
A-HYDROXYCAPRYLIC ACID
ALPHA-HYDROXYCAPRYLIC ACID
ALPHA HYDROXY OCTANOIC ACID
DL-2-HYDROXYOCTANOIC ACID
DL-ALPHA-HYDROXYCAPRYLIC ACID
2-Hydroxyoctanoicacid,98+%
Octanoic acid, 2-hydroxy-
Hydroxyoctanoic acid | [EINECS(EC#)]
210-524-3 | [Molecular Formula]
C8H16O3 | [MDL Number]
MFCD00014410 | [Molecular Weight]
160.21 | [MOL File]
617-73-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
66-68 °C | [Boiling point ]
226.12°C (rough estimate) | [density ]
1.0227 (rough estimate) | [refractive index ]
1.4310 (estimate) | [storage temp. ]
2-8°C
| [solubility ]
Chloroform (Sparingly), Methanol (Slightly) | [form ]
Solid | [pka]
3.86±0.21(Predicted) | [color ]
White to Off-White | [BRN ]
1760638 | [LogP]
1.960 (est) | [CAS DataBase Reference]
617-73-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [HS Code ]
2918.19.9000 |
| Hazard Information | Back Directory | [Uses]
2-Hydroxyoctanoic acid is a medium chain acyl-CoA synthetase inhibitor with a Ki of 500 μM[1]. | [Definition]
ChEBI: A hydroxy fatty acid that is caprylic (octanoic) acid substituted by a hydroxy group at position 2. | [Biological Activity]
(±)-2-Hydroxyoctanoic acid inhibits purified medium-chain acyl-CoA synthetase from bovine liver mitochondria (Ki500 uM) with hexanoic acid as a substrate .''(±)-2-Hydroxyoctanoic acid is a mixture of the D and L-2-hydroxyoctanoic acid enantiomers. (±)-2-Hydroxyoctanoic acid may be used in the development of medium-chain hydroxy-fatty acid enantiomer separation and detection systems. 2-Hydroxyoctanoic acid may be used as an inhibitor to study the kinteics of medium chain acyl-CoA synthetase(s). | [Purification Methods]
Crystallise the acid from EtOH/pet ether or ether/ligroin. [Beilstein 3 IV 873.] | [References]
[1] F Kasuya, et al. Inhibition of a medium chain acyl-CoA synthetase involved in glycine conjugation by carboxylic acids. Biochem Pharmacol. 1996 Nov 22;52(10):1643-6. DOI:10.1016/s0006-2952(96)00563-1 |
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