| Identification | More | [Name]
3,3-DIMETHYL-1-BUTANOL | [CAS]
624-95-3 | [Synonyms]
3,3-DIMETHYL-1-BUTANOL
NEOHEXANOL
3,3-dimethyl-1-butano
3,3-dimethyl-butan-1-ol
3,3-dimethylbutan-1-ol
3,3-Dimethylbutylalcohol
Dimethylbutanol
3,3-Dimethylbutanol
3,3-Dimethylbutane-1-ol | [EINECS(EC#)]
210-872-6 | [Molecular Formula]
C6H14O | [MDL Number]
MFCD00002928 | [Molecular Weight]
102.17 | [MOL File]
624-95-3.mol |
| Safety Data | Back Directory | [Risk Statements ]
R10:Flammable. | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S24/25:Avoid contact with skin and eyes . | [RIDADR ]
UN 1987 3/PG 3
| [WGK Germany ]
3
| [TSCA ]
Yes | [HazardClass ]
3.2 | [PackingGroup ]
III | [HS Code ]
29051990 |
| Hazard Information | Back Directory | [Chemical Properties]
colorless liqui | [Uses]
3,3-Dimethyl-1-butanol, is an organic building block used for the synthesis of various pharmaceutical compounds. It is an important intermediate in the synthesis of Neotame, an enhanced sweetening agent. | [General Description]
3,3-Dimethyl-1-butanol is a glass forming material. The molecular dynamics of 3,3-dimethyl-1-butanol was studied. | [in vivo]
3,3-Dimethyl-1-butanol (1% DMB soluble in water; p.o.; 6 weeks) significantly reduces the cardiac hypertrophy and fibrosis in heart failure (HF) mice[1].
3,3-Dimethyl-1-butanol (0.2% and 1.0% DMB soluble in water; p.o.; 21 d) increases the serum TMAO level with dose-dependent manner in ICR mice. 3,3-Dimethyl-1-butanol has been proved that the interaction between the gut and the brain has a regulatory effect on social behavior[2].
3,3-Dimethyl-1-butanol (1.0% DMB soluble in water; p.o.; gestation period and suckling period) prevents the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced hypertension in offspring of pregnant Sprague-Dawley rats[3].
| Animal Model: | C57BL6/J male mice (8-10 weeks old) with heart failure[1]. | | Dosage: | 1% DMB soluble in water. | | Administration: | Oral gavage; 6 weeks. | | Result: | Reduced the plasma trimethylamine N-oxide (TMAO) levels, the cross-sectional area of LV cardiomyocytes, and the area of LV interstitial fibrosis.
Decreased the expression of ANP, BNP, β-MHC, collagen Iα, collagen III and CTGF.
Inhibited TNF-α, IL-6, IL-1β, p65, TGF-β and Smad3 expression.
|
| Animal Model: | Male and female ICR mice (8-weeks old)[2]. | | Dosage: | 0.2% and 1.0% DMB soluble in water. | | Administration: | Oral gavage; 21 d. | | Result: | Showed insignificantly effect on body weight, water intake, food intake, sexual preference, anxiety, depression and memory formation.
Weakened the social dominance of mice.
|
| Animal Model: | Pregnant Sprague-Dawley rats[3]. | | Dosage: | 1.0% DMB soluble in water. | | Administration: | Oral gavage; gestation period and suckling period. | | Result: | Increased kidney weight, plasma trimethylamine (TMA) level and acetic acid, reduced diastolic.
Had significantly effect on gut microbiota composition.
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