| Identification | Back Directory | [Name]
3-broMo-5-Methanesulfonylaniline | [CAS]
62606-00-2 | [Synonyms]
3-broMo-5-Methanesulfonylaniline
3-BroMo-5-(Methylsulfonyl)aniline
3-Bromo-5-(methylsulfonyl)benzenamine
3-Bromo-5-(methylsulphonyl)aniline 98%
Benzenamine, 3-bromo-5-(methylsulfonyl)- | [Molecular Formula]
C7H8BrNO2S | [MDL Number]
MFCD17392822 | [MOL File]
62606-00-2.mol | [Molecular Weight]
250.11 |
| Chemical Properties | Back Directory | [Boiling point ]
452.9±45.0 °C(Predicted) | [density ]
1.671±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [pka]
1.58±0.10(Predicted) | [Appearance]
White to yellow Solid |
| Hazard Information | Back Directory | [Uses]
3-Bromo-5-(methylsulfonyl)aniline is used in the preparation of WDR5-?MYC inhibitors. | [Synthesis]
General procedure for the synthesis of 3-bromo-5-(methylsulfonyl)aniline from 1-bromo-3-(methylsulfonyl)-5-nitrobenzene: 1-bromo-3-(methylsulfonyl)-5-nitrobenzene (100 mg, 0.4 mmol) was dissolved in tetrahydrofuran (THF, 10 mL). Raney nickel catalyst was added and the hydrogenation reaction was carried out under 1 bar hydrogen pressure. Upon completion of the reaction, the mixture was filtered to remove the catalyst and the filtrate was subsequently concentrated. 3-Bromo-5-(methylsulfonyl)aniline (30 mg, 0.16 mmol, 40% yield) was finally obtained as a yellow solid. | [References]
[1] Patent: EP1953163, 2008, A1. Location in patent: Page/Page column 13
[2] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1977, p. 14 - 17 |
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