| Identification | More | [Name]
1-Amino-3-chloropropane hydrochloride | [CAS]
6276-54-6 | [Synonyms]
1-amino-3-chloropropane hydrochloride
3-AMINOPROPYL CHLORIDE HYDROCHLORIDE
3-CHLOROPROPYLAMINE HCL
3-CHLOROPROPYLAMINE HYDROCHLORIDE
3-chloropropylammonium chloride
3-CHLORPROPYLAMINE HYDROCHLORIDE
1-Propanamine, 3-chloro-, hydrochloride | [EINECS(EC#)]
228-474-6 | [Molecular Formula]
C3H9Cl2N | [MDL Number]
MFCD00012913 | [Molecular Weight]
130.02 | [MOL File]
6276-54-6.mol |
| Chemical Properties | Back Directory | [Appearance]
off-white to yellow-beige crystalline | [Melting point ]
145-150 °C(lit.)
| [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Crystalline Powder or Chunks | [color ]
Off-white to yellow-beige | [BRN ]
3667451 | [InChI]
InChI=1S/C3H8ClN.ClH/c4-2-1-3-5;/h1-3,5H2;1H | [InChIKey]
IHPRVZKJZGXTBQ-UHFFFAOYSA-N | [SMILES]
C(CCl)CN.Cl | [CAS DataBase Reference]
6276-54-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [HS Code ]
29211980 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
off-white to yellow-beige crystalline | [Uses]
3-Chloropropylamine hydrochloride was used in chemical treatment of carbon-enriched fly ash concentrates.It was used in the synthesis of linear, star and comb-like polyacrylamides by atomic transfer radical polymerization. It was used in the synthesis of halogen-functionalized aliphatic polyketones (macroinitiators). | [Synthesis]
General procedure for the synthesis of 3-chloropropylamine hydrochloride from 3-amino-1-propanol: An anhydrous chloroform (30 mL) solution of thionyl chloride (8.68 g, 1.32 mmol) was slowly added dropwise to 3-amino-1-propanol (4.49 g, 59.19 mmol) at 0-10°C. The reaction mixture was heated to room temperature and refluxed for 3 hours. The reaction mixture was gradually warmed to room temperature and then heated to reflux for 3 hours. After completion of the reaction, the mixture was cooled to room temperature and the precipitate was collected by filtration to afford the target product 3-chloropropylamine hydrochloride (7.07 g, 55.15 mmol, 93% yield) as a green solid. Electrospray mass spectrometry (ESMS) showed m/z 94 ([M+H]+). | [References]
[1] Patent: WO2014/18571, 2014, A2. Location in patent: Paragraph 00463
[2] Patent: WO2014/18570, 2014, A1. Location in patent: Paragraph 00261
[3] Angewandte Chemie - International Edition, 2018, vol. 57, # 19, p. 5413 - 5417
[4] Angew. Chem., 2018, vol. 130, p. 5511 - 5515,5 |
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