| Identification | Back Directory | [Name]
BERBERINE ACID SULFATE | [CAS]
633-66-9 | [Synonyms]
Nsc150444
berberinebisulfate
siarczanuberberyny
acidberberinesulfate
berberinesulfate(1:1)
BERBERINE SULFATE(RG)
HydroberbeaiMe Sulfate
BERBERINE ACID SULFATE
BERBERINE ACID SULPHATE
Berbamine sulphate acid
berberinehydrogensulfate
berberine hydrogen sulphate
BERBERINE SALTS/TENNATE
/HCL/B-SULPHATE/SULPHATE
Benzo[G]-1,3-benzodioxolo[5,6-A]quinolizinium, 5,6-dihydro-9,10-dimethoxy-, sulfate
Berbinium, 7,8,13,13A-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)-, sulfate (1:1)
Benzo[G]-1,3-benzodioxolo[5,6-A]quinolizinium, 5,6-dihydro-9,10-dimethoxy-, sulfate (1:1) | [EINECS(EC#)]
211-196-4 | [Molecular Formula]
C20H19NO8S | [MDL Number]
MFCD00075789 | [MOL File]
633-66-9.mol | [Molecular Weight]
433.43 |
| Questions And Answer | Back Directory | [Uses]
Berberine Sulfate is an isoquinoline alkaloid with chemopreventative properties. It is used in the preparation of derivatives showing activity against leishmaniasis and malaria. |
| Chemical Properties | Back Directory | [Melting point ]
274-275 °C (decomp) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [color ]
White to yellow | [Stability:]
Hygroscopic | [InChIKey]
OJVABJMSSDUECT-UHFFFAOYSA-L | [SMILES]
[O-]S([O-])(=O)=O.COc1ccc2cc3-c4cc5OCOc5cc4CC[n+]3cc2c1OC.COc6ccc7cc8-c9cc%10OCOc%10cc9CC[n+]8cc7c6OC |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
20/21/22 | [Safety Statements ]
36 | [RIDADR ]
1544 | [WGK Germany ]
3
| [RTECS ]
DR9867000
| [HazardClass ]
6.1(b) | [PackingGroup ]
III | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow needle-shaped crystals. Odorless, extremely bitter. MP 274°C. Soluble in water (1:30) and ethanol. | [in vivo]
Berberine sulfate (10, 30, or 50 mg/kg/day; gastrointestinal gavage; for 10 consecutive days) inhibits the growth of human colorectal adenocarcinoma in vivo. Berberine at doses of 30 and 50 mg/kg/day taken by gastrointestinal gavage shows inhibitory rates of 33.1% and 45.3% on the human colorectal adenocarcinoma xenograft growth in nude mice[1]. | Animal Model: | 5-week-old BALB/c nu/nu mice with human colorectal adenocarcinoma LoVo xenografts[1] | | Dosage: | 10, 30, or 50 mg/kg/day | | Administration: | Gastrointestinal gavage; for 10 consecutive days | | Result: | Showed inhibitory rates of 33.1% and 45.3% at doses of 30 and 50 mg/kg/day.
|
| [storage]
-20°C, sealed storage, away from moisture |
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