63302-99-8

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63302-99-8 Structure

Identification	Back Directory
[Name] Azaphenonxazine dihydrochloride Monohydrate
[CAS] 63302-99-8
[Synonyms] Azafen dihydrochloride Monohydrate Azaphen (dihydrochloride Monohydrate) Pipofezin dihydrochloride Monohydrate Pipofezine dihydrochloride Monohydrate Azaphenonxazine dihydrochloride Monohydrate 5-Methyl-3-(4-methyl-1-piperazinyl)-5H-pyridazino[3,4-b][1,4]benzoxazine dihydrochloride monohydrate AZAFEN DIHYDROCHLORIDE MONOHYDRATE;PIPOFEZIN DIHYDROCHLORIDE MONOHYDRATE;PIPOFEZINE DIHYDROCHLORIDE MONOHYDRATE;AZAPHENONXAZINE DIHYDROCHLORIDE MONOHYDRATE
[Molecular Formula] C16H23Cl2N5O2
[MDL Number] MFCD00220368
[MOL File] 63302-99-8.mol
[Molecular Weight] 388.292

Chemical Properties	Back Directory
[storage temp. ] Store at -20°C
[solubility ] Water: ≥ 100 mg/mL (257.54 mM); DMSO: 1 mg/mL (2.58 mM)
[form ] Solid
[color ] Light yellow to green yellow

Hazard Information	Back Directory
[Uses] Pipofezine(Azafen or Azaphen) is a potent inhibitor of the reuptake of serotonin. IC50 Value: Target: SSRIs Pipofezine is a tricyclic antidepressant (TCA) approved in Russia for the treatment ofdepression.
[References] [1] Shinaev NN, Akzhigitov RG. Azaphen: a return to clinical practice.Zh Nevrol Psikhiatr Im S S Korsakova. 2005;105(10):55-6. PMID:16281382 [2] Ignatowicz L, Ignatowicz R, Wdowiak MW, Jaremko A. Azaphen in the treatment of enuresis in children.Psychiatr Pol. 1977 Jan-Feb;11(1):29-33. PMID:557800 [3] Liberman SS, Sharova SA. A comparison of the effect of the tricyclic antidepressants azaphen and imizin on the gastrointestinal tracts of experimental animals.Farmakol Toksikol. 1975 Jan-Feb;38(1):29-32. PMID:1112390 [4] Misurec J, Náhunek K, Kamenická V, Chmelar M. Proceedings: Influence of azaphen, a new antidepressive drug, on the human EEG. Act Nerv Super (Praha). 1974;16(4):245-6. PMID:4450998

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