| Identification | Back Directory | [Name]
H-TYR-D-ALA-GLY-PHE-D-LEU-OH | [CAS]
63631-40-3 | [Synonyms]
YAGFL
DADLE
BW-180
TYR-D-ALA-GLY-PHE-D-LEU
(D-ALA2,D-LEU5)-ENKEPHALIN
H-TYR-D-ALA-GLY-PHE-D-LEU-OH
Enkephalin, Leucine-2-Alanine
TYR-D-ALA-GLY-PHE-D-LEU ACOH H2O
2-D-Alanine-5-D-leucine-enkephalin
(D-Ala2,D-Leu5)-Enkephalinv MW :
[D-ALA2,D-LEU5]-ENKEPHALIN ACOH H2O
H-TYR-D-ALA-GLY-PHE-D-LEU-OH USP/EP/BP
L-Tyrosyl-D-Alanylglycyl-L-Phenylalanyl-D-Leucine
D-Leucine, L-tyrosyl-D-alanylglycyl-L-phenylalanyl-
(D-Ala2,D-Leu5)-Enkephalin H-Tyr-D-Ala-Gly-Phe-D-Leu-OH | [Molecular Formula]
C29H39N5O7 | [MDL Number]
MFCD00076411 | [MOL File]
63631-40-3.mol | [Molecular Weight]
569.65 |
| Chemical Properties | Back Directory | [Melting point ]
>167°C (dec.) | [Boiling point ]
991.9±65.0 °C(Predicted) | [density ]
1.257±0.06 g/cm3(Predicted) | [storage temp. ]
-15°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
3.40±0.10(Predicted) | [color ]
White to Off-White | [Water Solubility ]
Soluble to 1 mg/ml in water | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
DADLE is a selective δ-?OR agonist. | [in vivo]
BW-180C ( [D-Ala2, D-Leu5]-Enkephalin; DADLE) protects liver against ischemia-reperfusion injury in the rat. DADLE (5 mg/kg) protects the heart, lung, and jejunum against ischemia-reperfusion (I-R) injury[2].
BW-180C (DADLE) improves hepatic ischemia/reperfusion injury in mice via activation of the Nrf2/HO1 pathway[3].
DADLE (5 mg/kg) significantly reduces the levels of alanine aminotransferase and aspartate aminotransferase in the serum, and the levels of malondialdehyde in the liver homogenate[3]. | Animal Model: | Male Wistar rats weighing 200 to 250 g[2] | | Dosage: | 5 mg/kg
| | Administration: | Administered intravenously into the inferior vena cava
| | Result: | After 120 min of reperfusion, the serum GPT levels were significantly lower in the DADLE group than in the Control group.
|
| Animal Model: | Male C57BL/6 mice (age, 35-42 days; weight, 18-22 g; 6 mice in each group)[3] | | Dosage: | 5 mg/kg
| | Administration: | Injected intraperitoneally 15 min prior to I/R
| | Result: | The serum levels of AST and ALT in the serum DADLE group were significantly lower.
|
| [storage]
Store at -20°C |
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