| Identification | More | [Name]
TETRAGLYCINE | [CAS]
637-84-3 | [Synonyms]
GLYCYL-GLYCYL-GLYCYL-GLYCINE
GLY-GLY-GLY-GLY
H-GLY-GLY-GLY-GLY-OH
TETRAGLYCINE
TRIGLYCYL-GLYCINE
([(([(Aminoacetyl)amino]acetyl)amino)acetyl]amino)acetic acid
Glycine, N-[N-(N-glycylglycyl)glycyl]-
N-[N-(N-glycylglycyl)glycyl]glycine
Glycyl-glycyl-glycyl-glycine, Tetraglycine, Triglycyl-glycine
Gly-Gly-Gly-Gly-OH | [EINECS(EC#)]
211-303-4 | [Molecular Formula]
C8H14N4O5 | [MDL Number]
MFCD00008129 | [Molecular Weight]
246.22 | [MOL File]
637-84-3.mol |
| Chemical Properties | Back Directory | [Appearance]
white powder | [Melting point ]
300 °C | [Boiling point ]
389.22°C (rough estimate) | [density ]
1.3853 (rough estimate) | [refractive index ]
1.6590 (estimate) | [storage temp. ]
−20°C
| [form ]
powder to crystal | [pka]
3.32±0.10(Predicted) | [color ]
White to Almost white | [BRN ]
1715387 | [CAS DataBase Reference]
637-84-3(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
white powder | [Uses]
peptide synthesis | [Biological Activity]
Tetraglycine is used with copper (Cu-II) to study mechanisms of hydrogen peroxide/bicarbonate free radical production and effect in vitro. | [in vivo]
Tetraglycine and Triglycine (1.0 μmol glycine/g body wt (246.22 mg/kg), injected into a central vein) results in greater glycine concentration in the kidney than injection of either Glycine.html" class="link-product" target="_blank">Glycine (HY-Y0966) or Diglycine[1]. | Animal Model: | Male Sprague-Dawley rats (270-300 g)[1] | | Dosage: | 1.0 μmol glycine/g body wt (246.22 mg/kg) | | Administration: | IV, injected over a period of 30 s | | Result: | Five minutes after the Tetraglycine injection, there were accumulations of diglvcine, triglvcine, and Tetraglycine in the kidney. |
| [Purification Methods]
Crystallise it from H2O (optionally, by the addition of EtOH). [Li et al. J Am Chem Soc 79 5859 1957, Rising et al. J Am Chem Soc 56 1179 1934, Beilstein 4 II 807, 4 III 1201, 4 IV 2472.] |
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