| Identification | Back Directory | [Name]
9ALPHA,15S-DIHYDROXY-11-OXO-PROSTA-5Z,12E-DIEN-1-OIC ACID | [CAS]
64072-89-5 | [Synonyms]
Δ12-PGD2
Brn 6071542
delta(sup12)-pgd2
Δ12-Prostaglandin D2
Δ12-Prostaglandin D2
DELTA12-PROSTAGLANDIN D2
delta(sup12)-prostaglandind2
9ALPHA,15S-DIHYDROXY-11-OXO-PROSTA-5Z,12E-DIEN-1-OIC ACID
(5Z,12E,15S)-9α,15-Dihydroxy-11-oxoprosta-5,12-dien-1-oic acid
(5z,9-alpha,12e,15s)-9,15-dihydroxy-11-oxoprosta-5,12-dien-1-oicacid
9,15-dihydroxy-11-oxo-,(5z,9-alpha,12e,15s)-prosta-12-dien-1-oicacid
Prosta-5,12-dien-1-oic acid, 9,15-dihydroxy-11-oxo-, (5Z,9α,12E,15S)-
Prosta-5,12-dien-1-oic acid, 9,15-dihydroxy-11-oxo-, (5Z,9-alpha,12E,15S)- | [Molecular Formula]
C20H32O5 | [MDL Number]
MFCD01694758 | [MOL File]
64072-89-5.mol | [Molecular Weight]
352.47 |
| Hazard Information | Back Directory | [Description]
Prostaglandin D2 (PGD2) is one of the five primary enzymatic prostaglandins derived directly from PGH2. PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, hematopoietic-type PGD synthase. PGD2 is chemically unstable, and its use and analysis is complicated by its short in vivo half-life. Δ12-PGD2 is one of the initial chemical decomposition products of PGD2. Δ12-PGD2 is an intermediate in the pathway leading to Δ12-PGJ2, which is a cyclopentenone prostaglandin with antimitotic and carcinogenic activities. The metabolism of Δ12-PGD2 involves addition of thiol nucleophiles, as is the case with the majority of cyclopentenone prostaglandins. | [Uses]
Δ12(E)-Prostaglandin D2 is a derivative of Prostaglandin D2 (HY-101988). Prostaglandin D2 is one of the major Prostaglandins actively produced in the brain of various mammals[1]. | [References]
[1] J Atsmon, et al. Formation of thiol conjugates of 9-deoxy-delta 9,delta 12(E)-prostaglandin D2 and delta 12(E)-prostaglandin D2. Biochemistry. 1990 Apr 17;29(15):3760-5. DOI:10.1021/bi00467a023 |
|
|