| Identification | Back Directory | [Name]
hainanolide | [CAS]
64761-48-4 | [Synonyms]
hainanolide
1H-3,10a-Methano-2,4-dioxacyclohepta[bc]cyclopent[jk]acenaphthylene-1,7(3H)-dione, 2a,4a,9,10,10b,10c-hexahydro-5,11-dimethyl-, (2aR,3R,4aR,10aS,10bS,10cR,11S)- | [Molecular Formula]
C19H18O4 | [MOL File]
64761-48-4.mol | [Molecular Weight]
310.35 |
| Hazard Information | Back Directory | [Uses]
Harringtonolide is a potent RACK1 inhibitor (IC50=39.66 μM in A375 cells). Harringtonolide inhibits the epithelial-mesenchymal transition (EMT) process and cell proliferation by affecting the interaction between FAK and RACK1. Harringtonolide has plant growth inhibitory, antiviral, anti-inflammatory, and antiproliferation activities[1]. | [References]
[1] Zhu TY, et al. Photoaffinity Probe Reveals the Potential Target of Harringtonolide for Cancer Cell Migration Inhibition. ACS Med Chem Lett. 2022;13(3):449-456. Published 2022 Feb 2. DOI:10.1021/acsmedchemlett.1c00625 |
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