| Identification | Back Directory | [Name]
S 2238 | [CAS]
64815-81-2 | [Synonyms]
S 2238
H-Phe-pip-Arg-pna
H-D-Phe-pip-Arg-pna
H-Phe-pip-Arg-p-nitroanilide
Chromogenic substrate S-2238
H-D-Phenylalanyl-pip-Arg-p-nitroanilide
H-D-Phenylalanyl-L-pipecolyl-arginine-nitroanilide
D-Phenylalanyl-L-2-piperidinecarbonyl-N-(4-nitro phenyl)-L-argininamide | [Molecular Formula]
C27H36N8O5 | [MDL Number]
MFCD07780999 | [MOL File]
64815-81-2.mol | [Molecular Weight]
552.625 |
| Chemical Properties | Back Directory | [density ]
1.405±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [solubility ]
DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly, Sonicated) | [form ]
Solid | [pka]
13.291±0.20(predicted) | [color ]
White to Off-White | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
H-D-Phe-Pip-Arg-pNA (S-2238), a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA is sensitive, accurate, and easy to perform[1][2]. | [References]
[1] Goodnight SH Jr, et al. Measurement of antithrombin III in normal and pathologic states using chromogenic substrate S-2238. Comparison with immunoelectrophoretic and factor Xa inhibition assays. Am J Clin Pathol. 1980;73(5):639-647. DOI:10.1093/ajcp/73.5.639
[2] Voorthuizen H, Kluft C. Improved assay conditions for automated antithrombin III determinations with the chromogenic substrate S-2238. Thromb Haemost. 1984;52(3):350-353. PMID:6531759 |
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