| Identification | Back Directory | [Name]
L-Leucyl-L-Leucine methyl ester (hydrochloride) | [CAS]
6491-83-4 | [Synonyms]
Leu-Leu-ome hydrochloride
H-Leu-leu-OMe hydrochloride
L-Leucyl-L-Leucine methyl ester (hydrochloride)
L-Leucine, L-leucyl-, methyl ester, monohydrochloride
methyl (2S)-2-[(2S)-2-amino-4-methylpentanamido]-4-methylpentanoate hydrochloride | [Molecular Formula]
C13H27ClN2O3 | [MDL Number]
MFCD00155477 | [MOL File]
6491-83-4.mol | [Molecular Weight]
294.818 |
| Chemical Properties | Back Directory | [Melting point ]
177-181°C | [storage temp. ]
Hygroscopic, Refrigerator, under inert atmosphere | [solubility ]
DMSO (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Description]
L-Leucyl-L-Leucine methyl ester (LLME) is a lysosomal condensation product that has been reported to be cytotoxic towards natural killer cells and CD4+ and CD8+ T lymphocytes without affecting helper T cells and B cells. It has also been shown to induce death of monocytes, polymorphonuclear leukocytes, and myeloid tumor cells. Upon entry into cells via receptor-mediated endocytosis, LLME undergoes a condensation process catalyzed by dipeptidyl peptidase I (DPPI) in lysosomes. This condensation leads to lysosomal rupture and DNA fragmentation in DPPI-expressing immune cells such as cytotoxic T cells and natural killer cells. | [Uses]
H-Leu-leu-OMe HCl | [storage]
Store at -20°C | [References]
[1] M OHLIN. The effect of leucyl-leucine methyl ester on proliferation and Ig secretion of EBV-transformed human B lymphocytes.[J]. Immunology, 1989, 66 4: 485-490.
[2] D L THIELE P E L. Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1990, 87 1: 83-87. DOI: 10.1073/pnas.87.1.83 |
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| Company Name: |
Shanghai GL Peptide Ltd.
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| Tel: |
+86-21-61263340; 17609490614 13764994101 |
| Website: |
https://www.chemicalbook.com/supplier/10480342/ |
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