65236-62-6

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65236-62-6 Structure

Identification	Back Directory
[Name] Dehydrocrenatidine
[CAS] 65236-62-6
[Synonyms] TOP3 TOP-3 TOP 3 Dehydrocrenatidine O-Methylpicrasidine I 1-ethenyl-4,8-dimethoxy-9H-pyrido[3,4-b]indole 9H-Pyrido[3,4-b]indole, 1-ethenyl-4,8-dimethoxy-
[Molecular Formula] C15H14N2O2
[MDL Number] MFCD17214777
[MOL File] 65236-62-6.mol
[Molecular Weight] 254.28

Chemical Properties	Back Directory
[form ] Solid
[color ] Off-white to light yellow

Safety Data	Back Directory
[Symbol(GHS) ] GHS07
[Signal word ] Warning
[Hazard statements ] H302-H315-H319-H335
[Precautionary statements ] P261-P305+P351+P338

Hazard Information	Back Directory
[Uses] Dehydrocrenatidine, a natural alkaloid, is a specific JAK inhibitor. Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain[1][2].
[in vivo] Dehydrocrenatidine inhibits JAK-STAT3 dependent DU145 and MDA-MB-468 cell survival and induces cell apoptosis. Dehydrocrenatidine inhibits JAKs-JH1 domain over-expression induced STAT3 and STAT1 phosphorylations^[1]. Dehydrocrenatidine diminishes IL-6, IFNα and IFNγ stimulated STAT3 phosphorylation as well as constitutive STAT3 phosphorylation^[1]. DHCT suppresses both tetrodotoxin-resistant (TTX-R) and sensitive (TTX-S) voltage-gated sodium channel (VGSC) currents with IC₅₀ values of 12.36 μM and 4.87 μM, respectively^[2].
[References] [1] Jing Zhang, et al. Dehydrocrenatidine is a novel janus kinase inhibitor. Mol Pharmacol. 2015 Apr;87(4):572-81. DOI:10.1124/mol.114.095208 [2] Fang Zhao, et al. Dehydrocrenatidine Inhibits Voltage-Gated Sodium Channels and Ameliorates Mechanic Allodia in a Rat Model of Neuropathic Pain. Toxins (Basel). 2019 Apr 18;11(4):229. DOI:10.3390/toxins11040229

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