| Identification | Back Directory | [Name]
1H-1,2,3-Triazole-4-carboxamide, N,1-bis(4-nitrophenyl)-5-phenyl- | [CAS]
660817-08-3 | [Synonyms]
CAP-53194
1H-1,2,3-Triazole-4-carboxamide, N,1-bis(4-nitrophenyl)-5-phenyl- | [Molecular Formula]
C21H14N6O5 | [MOL File]
660817-08-3.mol | [Molecular Weight]
430.37 |
| Hazard Information | Back Directory | [Description]
CAP-53194 is a potent and selective Plk1 inhibitor. | [Uses]
CAP-53194 is a selective Plk1 inhibitor with potential anticancer activity. CAP-53194 was identified by a high-throughput virtual screening approach using molecular docking, showing 100-fold selectivity for Plk1 over Plk2-4 and other cell cycle kinases. CAP-53194 is able to effectively exploit subtle differences between the binding sites of Plk1 and other Ser/Thr kinases, thereby enhancing their inhibitory effects. CAP-53194 meets the Lipinski compound analog criteria and passes other ADMET filters, indicating good compound compatibility. CAP-53194 belongs to a new class of potential Plk1 inhibitors suitable for subsequent compound development and testing[1]. | [References]
[1] Identification of a high affinity selective inhibitor of Polo-like kinase 1 for cancer chemotherapy by computational approach |
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