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663599-05-1

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663599-05-1 Structure

663599-05-1 Structure

Identification	Back Directory
[Name] Butanoic acid, 4-[[5-[(dimethylamino)carbonyl]-2-pyridinyl]dithio]-, 2,5-dioxo-1-pyrrolidinyl ester
[CAS] 663599-05-1
[Synonyms] DMAC-SPDB Butanoic acid, 4-[[5-[(dimethylamino)carbonyl]-2-pyridinyl]dithio]-, 2,5-dioxo-1-pyrrolidinyl ester
[Molecular Formula] C16H19N3O5S2
[MDL Number] MFCD20227785
[MOL File] 663599-05-1.mol
[Molecular Weight] 397.47

Chemical Properties	Back Directory
[Boiling point ] 586.7±60.0 °C(Predicted)
[density ] 1.42±0.1 g/cm3(Predicted)
[pka] 0.57±0.29(Predicted)

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[Uses] DMAC-SPDB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
[IC 50] Disulfide Cleavable Linker; Cleavable Linker
[References] [1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

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