| Identification | Back Directory | [Name]
esculentoside H | [CAS]
66656-92-6 | [Synonyms]
esculentoside H
Phytolaccasaponin B
ESCULENTOSIDE H (ESH)
3-O-(O-beta-D-glucopyranosyl-(1→
4)-beta-D-xylopyranosyl)-28-beta-D-glucopyranosylphytolaccagenin
3-O-(O-beta-D-glucopyranosyl-(1-4)-beta-D-xylopyranosyl)-28-beta-D-glucopyranosylphytolaccagenin
Olean-12-ene-28,29-dioic acid, 3-[(4-O-β-D-glucopyranosyl-β-D-xylopyranosyl)oxy]-2,23-dihydroxy-, 28-β-D-glucopyranosyl 29-methyl ester, (2β,3β,4α,20β)- | [Molecular Formula]
C48H76O21 | [MDL Number]
MFCD29049459 | [MOL File]
66656-92-6.mol | [Molecular Weight]
989.1 |
| Chemical Properties | Back Directory | [Boiling point ]
1042.8±65.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
12.52±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Esculentoside H (EsH) is a saponin isolated from the root extract of perennial plant Phytolacca esculenta[1].
Esculentoside H (EH) has anti-tumor activity, the mechanism is related to the capacity for TNFrelease[2].
Esculentoside H (EsH) suppresses colon cancer cell migration through blockage of the JNK1/2 and NF-κB signaling-mediated matrix metalloproteinases-9 (MMP-9) expression[1]. | [References]
[1] Ha SH, et al. Esculentoside H inhibits colon cancer cell migration and growth through suppression of MMP-9 gene expression via NF-kB signaling pathway. J Cell Biochem. 2019 Jun;120(6):9810-9819. DOI:10.1002/jcb.28261
[2] Hu ZL, et al. Effect of esculentoside H on release of tumor necrosis factor from mouse peritoneal macrophages. Zhongguo Yao Li Xue Bao. 1993 Nov;14(6):550-2. PMID:8010057 |
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