| Identification | Back Directory | [Name]
TGF-beta RI Kinase Inhibitor VII | [CAS]
666729-57-3 | [Synonyms]
TGF-β RI Kinase Inhibitor VII
TGF-beta RI Kinase Inhibitor VII
1-(2-((6,7-Dimethoxyquinolin-4-yl)oxy)-4,5-dimethylphenyl)ethan-1-one | [Molecular Formula]
C21H21NO4 | [MOL File]
666729-57-3.mol | [Molecular Weight]
351.396 |
| Hazard Information | Back Directory | [Uses]
TGF-βRI inhibitor 3 (Compound 9ac) is a selective TGF-β inhibitor. TGF-βRI inhibitor 3 can effectively inhibit the TGF-β signaling pathway. TGF-βRI inhibitor 3 has IC50 values of 13 μM and 0.63 μM for c-Src kinase and ALK5 kinase, respectively[1]. | [References]
[1] Shimizu T, et al. Synthesis and evaluation of [2-(4-quinolyloxy)phenyl]methanone derivatives: novel selective inhibitors of transforming growth factor-beta kinase. J Med Chem. 2008 Jun 12;51(11):3326-9. DOI:10.1021/jm701626z |
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