| Identification | Back Directory | [Name]
Mizagliflozin | [CAS]
666843-10-3 | [Synonyms]
Mizagliflozin
DSP-3235 free base
KGA-3235 free base
GSK-1614235 free base
Propanamide, 3-[[3-[4-[[3-(β-D-glucopyranosyloxy)-5-(1-methylethyl)-1H-pyrazol-4-yl]methyl]-3-methylphenoxy]propyl]amino]-2,2-dimethyl- | [Molecular Formula]
C28H44N4O8 | [MOL File]
666843-10-3.mol | [Molecular Weight]
564.67 |
| Chemical Properties | Back Directory | [Boiling point ]
837.0±65.0 °C(Predicted) | [density ]
1.274±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
Methanol: 250 mg/mL (442.74 mM); DMSO: 100 mg/mL (177.09 mM) | [form ]
Solid | [pka]
12.65±0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Mizagliflozin (DSP-3235 free base) is a potent, orally active and selective SGLT1 inhibitor, with a Ki of 27 nM for human SGLT1. Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic agent that can modify postprandial blood glucose excursion. Mizagliflozin also exhibits potential in the amelioration of chronic constipation[1]. | [in vivo]
Mizagliflozin (DSP-3235 free base) (3-30 mg/kg; oral) exerts a laxative effect[1].
Mizagliflozin administrated intravenously (0.3 mg/kg) and orally (3 mg/kg) declined with a short half-life (0.23 and 1.14 h, respectively)[2] | Animal Model: | Male Wistar rats (rat model of low-fiber-diet-induced constipation)[1] | | Dosage: | 3, 10, 30 mg/kg | | Administration: | Oral | | Result: | Increased fecal wet weight in a rat model of low-fiber-diet-induced constipation. |
| [IC 50]
SGLT1 | [storage]
4°C, protect from light | [References]
[1] Inoue T, et al. Mizagliflozin, a novel selective SGLT1 inhibitor, exhibits potential in the amelioration of chronic constipation. Eur J Pharmacol. 2017 Jul 5;806:25-31. DOI:10.1016/j.ejphar.2017.04.010
[2] Ohno H, et al. Absorption, disposition, metabolism and excretion of [14C]mizagliflozin, a novel selective SGLT1 inhibitor, in rats. Xenobiotica. 2019 Apr;49(4):463-473. DOI:10.1080/00498254.2018.1449269 |
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Twochem Co.Ltd
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021-021-58111628 15800915896 |
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www.twochem.com |
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Wuhan Topule
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http://www.topule.com/ |
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