| Identification | Back Directory | [Name]
Pepluanin A | [CAS]
670257-89-3 | [Synonyms]
Pepluanin A
3-Pyridinecarboxylic acid, (2R,3R,3aS,4R,6S,7S,8S,10E,12S,13S,13aR)-2,4,6,7,13-pentakis(acetyloxy)-3-(benzoyloxy)-2,3,3a,4,5,6,7,8,9,12,13,13a-dodecahydro-13a-hydroxy-2,9,9,12-tetramethyl-5-methylene-1H-cyclopentacyclododecen-8-yl ester | [Molecular Formula]
C43H51NO15 | [MDL Number]
MFCD20274644 | [MOL File]
670257-89-3.mol | [Molecular Weight]
821.86 |
| Hazard Information | Back Directory | [Uses]
Pepluanin A is a natural compound isolated from Euphorbia peplus L. Pepluanin A shows a very high activity for a jatrophane diterpene, outperforming Cyclosporin A by a factor of at least 2 in the inhibition of Pgp-mediated Daunomycin (HY-13062A) transport[1] | [References]
[1] Corea G, et al. Jatrophane diterpenes as modulators of multidrug resistance. Advances of structure-activity relationships and discovery of the potent lead pepluanin A. J Med Chem. 2004;47(4):988-992. DOI:10.1021/jm030951y |
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