| Identification | Back Directory | [Name]
SM 324405 | [CAS]
677773-91-0 | [Synonyms]
SM 324405
Methyl 3-[(6-amino-2-butoxy-7,8-dihydro-8-oxo-9H-purin-9-yl)methyl]benzeneacetate
methyl {3-[(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)methyl]phenyl}acetate
Benzeneacetic acid, 3-[(6-amino-2-butoxy-7,8-dihydro-8-oxo-9H-purin-9-yl)methyl]-, methyl ester | [Molecular Formula]
C19H23N5O4 | [MDL Number]
MFCD30182295 | [MOL File]
677773-91-0.mol | [Molecular Weight]
385.42 |
| Chemical Properties | Back Directory | [Melting point ]
246-251 °C | [density ]
1.304±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 100 mM | [form ]
A crystalline solid | [pka]
10.05±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SM 324405 is a TLR7 agonist. | [in vivo]
SM-324405 (9e, intratracheal administration) effectively inhibits allergen-induced airway inflammation without inducing cytokines systemically[1].
SM-324405 is metabolized to the corresponding acid in human plasma with t1/2 of 2.6 min[1][2].
| [IC 50]
TLR7: 50 nM (EC50); human TLR7: 7.3 (pEC50); Rat TLR7: 6.6 (pEC50) | [storage]
Store at +4°C |
|
| Company Name: |
Wuhan Topule
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+86-02787215551 19945035818 |
| Website: |
http://www.topule.com/ |
| Company Name: |
cjbscvictory
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13348960310 13348960310; |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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