| Identification | More | [Name]
Caronic anhydride | [CAS]
67911-21-1 | [Synonyms]
6,6-Dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione
caronic anhydride
aronicanhydride | [Molecular Formula]
C7H8O3 | [MDL Number]
MFCD09751198 | [Molecular Weight]
140.14 | [MOL File]
67911-21-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
53-57℃ | [Boiling point ]
246°C | [density ]
1.274 | [Fp ]
113°C | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
soluble in Methanol | [form ]
Solid | [color ]
White | [Sensitive ]
Moisture Sensitive | [InChI]
InChI=1S/C7H8O3/c1-7(2)3-4(7)6(9)10-5(3)8/h3-4H,1-2H3 | [InChIKey]
QKAHKEDLPBJLFD-UHFFFAOYSA-N | [SMILES]
C12C(C1(C)C)C(=O)OC2=O | [CAS DataBase Reference]
67911-21-1(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder | [Uses]
Caronic anhydride, also known as 6,6-Dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione, is a pharmaceutical intermediate mainly used as a synthesis of Boceprevir, an oral protease inhibitor of hepatitis C. It is widely used in agricultural chemicals and other organic synthesis field.
| [Synthesis]
Step 1: Ethyl dichlorochrysanthemate in ethyl acetate is ozonized at -5°C until conversion exceeds 99%. Work-up, saponification, acidification, extraction, and concentration yield 3,3-dimethyl-1,2-cyclopropanedicarboxylic acid.
Step 2: The diacid is he |
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