| Identification | Back Directory | [Name]
OL-135 | [CAS]
681135-77-3 | [Synonyms]
OL-135
1-Oxo-1-[5-(2-pyridyl)oxazol-2-yl]-7-phenylheptane
7-Phenyl-1-[5-(2-pyridinyl)-2-oxazolyl]-1-heptanone
1-Heptanone, 7-phenyl-1-[5-(2-pyridinyl)-2-oxazolyl]-
7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one | [Molecular Formula]
C21H22N2O2 | [MOL File]
681135-77-3.mol | [Molecular Weight]
334.41 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble5mg/mL, clear (warmed) | [form ]
powder | [color ]
white to beige | [InChI]
1S/C21H22N2O2/c24-19(14-7-2-1-4-10-17-11-5-3-6-12-17)21-23-16-20(25-21)18-13-8-9-15-22-18/h3,5-6,8-9,11-13,15-16H,1-2,4,7,10,14H2 | [InChIKey]
ILOIOIGZFHGSMS-UHFFFAOYSA-N | [SMILES]
n1c([o]c(c1)c3ncccc3)C(=O)CCCCCCc2ccccc2 |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
43 | [Safety Statements ]
36/37 | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Aquatic Chronic 4 |
| Hazard Information | Back Directory | [Uses]
OL-135 is a CNS penetrant, selective, and reversible of FAAH inhibitor. OL-135 exhibits analgesic activity[1]. | [Biological Activity]
OL-135 is a CNS penetranthighly potent and selective reversible inhibitor of FAAH devoid of CB1CB2 and μ and δ opioid receptors activities th at increases the analgesic and hypothermic activity of anandamide. | [References]
[1] Duncan KK, et al. α-Ketoheterocycle inhibitors of fatty acid amide hydrolase: exploration of conformational constraints in the acyl side chain. Bioorg Med Chem. 2014;22(9):2763-2770. DOI:10.1016/j.bmc.2014.03.013 |
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