| Identification | More | [Name]
2-Aminocyclohexanol | [CAS]
6850-38-0 | [Synonyms]
2-AMINOHYDROXYCYCLOHEXANE
TIMTEC-BB SBB004300
aminocyclohexanol
2-Aminocyclohenxanol
2-Aminocyclohexanol 98%
2-Aminocyclohexanol98%
1-Amino-2-hydroxycyclohexane
2-Aminocyclohexanol (cis-and trans-mixture) | [Molecular Formula]
C6H13NO | [MDL Number]
MFCD00191368 | [Molecular Weight]
115.17 | [MOL File]
6850-38-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
65 °C | [Boiling point ]
212 °C | [density ]
1.037±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [pka]
14.94±0.40(Predicted) | [color ]
White to Light orange to Yellow | [InChIKey]
PQMCFTMVQORYJC-UHFFFAOYSA-N | [CAS DataBase Reference]
6850-38-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
3259 | [Hazard Note ]
Irritant | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
2922190090 |
| Hazard Information | Back Directory | [Chemical Properties]
White to Light orange to Yellow powder to crystal. | [Uses]
Trans-2-aminocyclohexanol and cis-/trans-1,2-cyclohexanediamines have found their application in the synthesis of the antiarrhythmic medicament vernakalant and spleen tyrosine kinase inhibitor, κ-opioid analgesics. | [Preparation]
2-Aminocyclohexanol Synthesis: Under water bath reaction conditions, 214.3 g of ammonia water was added to a 500 mL three-necked flask. Stir and heat, and when the internal temperature reaches about 50°C, start to slowly drop 50.0 g of 1,2-epoxycyclohexane into the reaction flask. After the dropwise addition was completed, the reaction was performed at a constant temperature for 12h. After the reaction was completed, the reaction was processed to obtain a crude product, which was purified by recrystallization to obtain 2-aminocyclohexanol with a yield of 90% and an amine value (mgKOH/g) of 453. |
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