| Identification | Back Directory | [Name]
RR-11a analog | [CAS]
685543-66-2 | [Synonyms]
RR-11a analog
L-Alanine, N-[(phenylmethoxy)carbonyl]-L-alanyl-, 2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-1,4-dioxo-2-buten-1-yl]hydrazide | [Molecular Formula]
C22H29N5O8 | [MDL Number]
MFCD31813786 | [MOL File]
685543-66-2.mol | [Molecular Weight]
491.49 |
| Chemical Properties | Back Directory | [density ]
1.291±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 125 mg/mL (254.33 mM; Need ultrasonic) | [form ]
Solid | [pka]
10.13±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
RR-11a analog is a potent and irreversible inhibitor of Schistosoma mansoni legumain, with an IC50 of 31 nM. RR-11a analog is an aza-Asn derivative and aza-peptide Michael acceptor[1][2]. | [in vivo]
RR-11a analog has a half-live of 3-10 min[2]. | [References]
[1] G?tz MG, et al. Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens. J Med Chem. 2008 May 8;51(9):2816-32. DOI:10.1021/jm701311r
[2] Ekici OD, et al. Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. J Med Chem. 2004 Apr 8;47(8):1889-92. DOI:10.1021/jm049938j |
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