| Identification | Back Directory | [Name]
Bis-Tos-(2-hydroxyethyl disulfide) | [CAS]
69981-39-1 | [Synonyms]
Bis-Tos-(2-hydroxyethyl disulfide)
Bis-tosyl-(2-hydroxyethyl disulfide) | [Molecular Formula]
C18H22O6S4 | [MDL Number]
MFCD28976689 | [MOL File]
69981-39-1.mol | [Molecular Weight]
462.62 |
| Chemical Properties | Back Directory | [Melting point ]
69 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
625.6±50.0 °C(Predicted) | [density ]
1.360±0.06 g/cm3(Predicted) | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Bis-Tos-(2-hydroxyethyl disulfide) contains a cleavable disulfide bond and two tosyl moieties. Tosyl is a good leaving group and can be replaces by a nucleophiles. The disulfide bond can be cleaved via reduction. | [Uses]
Bis-Tos-(2-hydroxyethyl disulfide) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | [IC 50]
Disulfide Cleavable Linker; Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
|
|