| Identification | More | [Name]
4'-Hydroxypropiophenone | [CAS]
70-70-2 | [Synonyms]
1-(4-METHOXYPHENYL)ETHANONE
4-ACETOANISOLE
4-ACETYLANISOLE
4-HYDROXYPHENYL ETHYL KETONE
4'-HYDROXYPROPIOPHENONE
4-HYDROXYPROPIOPHENONE
4'-METHOXYACETOPHENONE
4-METHOXYACETOPHENONE
4-METHOXYPHENYLETHANONE
ACETANISOLE
AKOS 90580
AKOS BBS-00003216
AKOS BBS-00003225
AURORA 5371
ETHYL 4-HYDROXYPHENYL KETONE
FEMA 2005
LABOTEST-BB LT00855519
LABOTEST-BB LT01595901
P-ACETANISOLE
P-ACETYLANISOLE | [EINECS(EC#)]
202-815-9 | [Molecular Formula]
C9H10O2 | [MDL Number]
MFCD00008745 | [Molecular Weight]
150.17 | [MOL File]
70-70-2.mol |
| Chemical Properties | Back Directory | [Appearance]
white powder | [Melting point ]
36-38 °C(lit.)
| [Boiling point ]
152-154 °C26 mm Hg(lit.)
| [bulk density]
300-400kg/m3 | [density ]
1.09 g/cm3 (20℃) | [FEMA ]
2005 | ACETANISOLE | [refractive index ]
1.5360 (estimate) | [Fp ]
>230 °F
| [storage temp. ]
Store below +30°C. | [solubility ]
methanol: 0.1 g/mL, clear
| [form ]
Solid | [pka]
8.87±0.26(Predicted) | [color ]
White | [Water Solubility ]
0.34 g/l (15 ºC) | [Usage]
Intermediates of Liquid Crystals | [Merck ]
14,7044 | [BRN ]
907511 | [InChI]
1S/C9H10O2/c1-2-9(11)7-3-5-8(10)6-4-7/h3-6,10H,2H2,1H3 | [InChIKey]
RARSHUDCJQSEFJ-UHFFFAOYSA-N | [SMILES]
CCC(=O)c1ccc(O)cc1 | [LogP]
2.030 | [CAS DataBase Reference]
70-70-2(CAS DataBase Reference) | [NIST Chemistry Reference]
1-Propanone, 1-(4-hydroxyphenyl)-(70-70-2) | [EPA Substance Registry System]
70-70-2(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P280a-P304+P340-P305+P351+P338-P405-P501a | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S37:Wear suitable gloves .
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [RTECS ]
UH1925000
| [TSCA ]
Yes | [HS Code ]
29145000 | [Storage Class]
11 - Combustible Solids | [Safety Profile]
Poison by
intraperitoneal, subcutaneous, and parenteral
routes. An experimental teratogen. Other
experimental reproductive effects. A
flammable liquid. When heated to
decomposition it emits acrid smoke and
irritating fumes. See also KETONES. | [Hazardous Substances Data]
70-70-2(Hazardous Substances Data) | [Toxicity]
LD50 orally in Rabbit: 11800 mg/kg |
| Hazard Information | Back Directory | [Chemical Properties]
white powder | [Uses]
gonadotropic hormone inhibitor | [Uses]
Intermediates of Liquid Crystals | [Uses]
p-Hydroxypropiophenone is a 4-hydroxyphenyl ketone used in the preparation of potential antitumor agents. p-Hydroxypropiophenone is a lignin degrradation product. | [Definition]
ChEBI: P-Hydroxypropiophenone is a member of acetophenones. | [Preparation]
Preparation by Fries rearrangement of phenyl propionate
with aluminium chloride in refluxing carbon disulfide ? then at 130–150° for 2–3 h after solvent elimination (45–50%)
with aluminium chloride in nitrobenzene at 50° for 18 h (72%) or at ? 20° for 48 h (60%)
with aluminium chloride in nitromethane at 20° for 7–8 days (80%)
with aluminium chloride in chlorobenzene using microwave irradiation for ? 3 min at 106° (62%)
with aluminium chloride in ethylene dichloride at 95° for 5 h or in heptane at ? 80–90° for 7 h (36%), in benzene or in tetrachloroethane at 80°; with aluminium chloride in the presence of propionyl chloride at 50–60° for ? 6 h (49%)
with aluminium chloride without solvent at 50° for 10 h
with titanium tetrachloride in nitromethane at 20° for 7 days (56%) or ? without solvent at 50° for 10 h (39%)
with polyphosphoric acid at 100° (61%)
with boron trifluoride at 50° for 3 h (46%)
with stannic chloride at 50° for 3 h (10%). | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 30, p. 2491, 1965 DOI: 10.1021/jo01018a528 | [target]
Estrogen receptor | [Purification Methods]
4'-Hydroxypropiophenone [70-70-2] M 150.2, m 149o, b 140-145o/0.5mm, 8.05. Crystallise the phenone from H2O (m 149.8-150.2o) or EtOH (m 147o). The benzoyl derivative has m 117o, and the semicarbazone has m 183o (EtOH). [Beilstein 8 H 102, 8 II 104, 8 III 379.] |
|
| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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