| Identification | More | [Name]
Terazosin hydrochloride dihydrate | [CAS]
70024-40-7 | [Synonyms]
TERAZOSIN HCL 2H2O
TERAZOSIN HYDROCHLORIDE DIHYDRATE
TERAZOSIN MONOHYDROCHLORIDE DIHYDRATE
arbonyl)-,monohydrochloride,dihydrate
Hytrinex
iperazinehcl2h2o
Terazosin HCL dihydrate
TerazosinHclC19H26C1N504
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furanyl-)carbonyl)-piperazine hydrochloride dihydrate | [EINECS(EC#)]
629-697-5 | [Molecular Formula]
C19H30ClN5O6 | [MDL Number]
MFCD00941408 | [Molecular Weight]
459.92 | [MOL File]
70024-40-7.mol |
| Chemical Properties | Back Directory | [Appearance]
White or slightly yellow, crystalline powder. | [Melting point ]
271-274°C | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Sparingly soluble in water, slightly soluble in methanol, very slightly soluble in ethanol (96 per cent), practically insoluble in acetone. | [form ]
neat | [color ]
White | [Major Application]
pharmaceutical (small molecule) | [InChI]
1S/C19H25N5O4.ClH.2H2O/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;;;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H;2*1H2 | [InChIKey]
NZMOFYDMGFQZLS-UHFFFAOYSA-N | [SMILES]
O=C(C1CCCO1)N1CCN(C2N=C3C(C=C(C(=C3)OC)OC)=C(N)N=2)CC1.[H]Cl.[H]O[H].[H]O[H] | [CAS DataBase Reference]
70024-40-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22 | [WGK Germany ]
WGK 3 | [RTECS ]
TK8046000 | [HS Code ]
2934990002 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2 | [Toxicity]
LD50 in male, female rats (mg/kg): 277, 293 i.v. (Fort) |
| Hazard Information | Back Directory | [Chemical Properties]
White or slightly yellow, crystalline powder. | [Uses]
analgesic, antiinflammatory | [Manufacturing Process]
To a solution of n-butanol (316 ml), water (24 ml) and N-(2-
tetrahydrofuroyl)piperazine (20 g) were added, while stirring, 4-amino-2-
chloro-6,7-dimethoxyquinazoline (22.2 g). The reaction mixture was heated to
reflux and the reflux was maintained for about 9 h. Then the reaction mixture
was cooled to room temperature and stirred at this temperature for about 10-
12 h. The crystals were collected by filtration, washed with n-BuOH and dried
in vacuo at 40-50°C to yield 40.1 g (94%) of the 1-(4-amino-6,7-dimethoxy-
2-quinazolinyl)-4-(tetrahydrofuroyl)piperazine hydrochloride dihydrate | [Therapeutic Function]
Antihypertensive |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Spectrum Chemical Manufacturing Corp.
|
| Telephone: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
|