| Identification | Back Directory | [Name]
BPV(HOPIC) | [CAS]
722494-26-0 | [Synonyms]
BPV(HOPIC)
K2[VO(O2)2C6H4NO3]
Bisperoxovanadium(HOpic)
bpV(HOpic) (potassium salt)
bpV(HOpic) (potassium salt, technical grade)
DIPOTASSIUM BISPEROXO(5-HYDROXYPYRIDINE-2-CARBOXYL)OXOVANADATE (V) | [Molecular Formula]
C6H4K2NO8V | [MDL Number]
MFCD01862576 | [MOL File]
722494-26-0.mol | [Molecular Weight]
347.24 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
H2O: soluble20mg/mL, clear | [form ]
powder | [color ]
faint yellow to dark yellow | [Water Solubility ]
water: 4mg/mL | [InChI]
1S/C6H5NO3.2K.2O2.4H2O.O.V/c8-4-1-2-5(6(9)10)7-3-4;;;2*1-2;;;;;;/h2-3H,1H2,(H,9,10);;;;;4*1H2;;/q;2*+1;2*-2;;;;;-1;+4/p-1 | [InChIKey]
HSCJTESZNNRNPK-UHFFFAOYSA-M | [SMILES]
[V]32(OO3)(OO2)([NH]1=CC(=O)CC=C1C(=O)[O-])[O-].[K+].[K+].O.O.O.O |
| Hazard Information | Back Directory | [Uses]
bpV(HOpic) has been used in pharmacological perturbation of cell migration related signaling pathway. | [Biochem/physiol Actions]
bpV(OHpic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN, phosphatase and tensin homolog, a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(HOpic) are 14 nM for PTEN compared to 4.9 μM for PTPβ and 25.3 μM for PTP-1β. bpV(HOpic) has been shown to enhance PI3K/Akt signaling that could prevent myocardium from ischemia-reperfusion injury. | [in vivo]
BpV(HOpic) (0.05 mg/kg; i.p.) at reperfusion ameliorates liver ischemia/reperfusion (I/R) injury in vivo[6].
BpV(HOpic) (200 μg/kg; i.p.) exacerbates renal dysfunction and promotes tubular damage in mice with ischemia/reperfusion injury (IRI)[7]. | Animal Model: | Male Wistar rats are subjected to partial hepatic ischemia[6] | | Dosage: | 0.05 mg/kg | | Administration: | I.p. injections at the start of reperfusion | | Result: | Ameliorated reoxygenation injury and reproduced the hepatoprotective effects obtained by adenosine A2A receptor stimulation. |
| Animal Model: | Male C57BL/6 mice (8-12 weeks old; 20-30 g ) are subjected to renal ischemia[7] | | Dosage: | 200?μg/kg | | Administration: | I.p. injections 1?h before ischemia and then administers every 6?h after ischemia for 24 hr | | Result: | Raised the level of serum creatinine and blood serum urea nitrogen. |
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| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
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