| Identification | Back Directory | [Name]
3,4,5-trimethoxy-N-[4-(8-methylimidazo[1,2-a]pyridin-2-yl)phenyl]benzamide | [CAS]
724737-74-0 | [Synonyms]
Protein deglycase DJ-1 against-1
Benzamide, 3,4,5-trimethoxy-N-[4-(8-methylimidazo[1,2-a]pyridin-2-yl)phenyl]- | [Molecular Formula]
C24H23N3O4 | [MOL File]
724737-74-0.mol | [Molecular Weight]
417.46 |
| Hazard Information | Back Directory | [Uses]
Protein deglycase DJ-1 against-1, a DJ-1-binding compound, dependently targets DJ1. Protein deglycase DJ-1 against-1 penetrates through the blood brain barrier (BBB). Protein deglycase DJ-1 against-1 is used as a neuroprotective agent and has the potential for Parkinson's disease research[1]. | [in vivo]
Protein deglycase DJ-1 against-1 (compound-23; 1 mg/kg; IP; pretreatment one hour; daily; for 4 days) significantly restores MPTP induced locomotion, dopaminergic neuronal cell death and dopamine content in DJ-1(+/+) mice but not in DJ-1(-/-) mice[1]. | Animal Model: | Wild-type male C57BL/6 mice at 8, 11-12 and 9-12 weeks; DJ-1-knockout male mice at 11-13 weeks[1] | | Dosage: | 1 mg/kg | | Administration: | IP; pretreatment one hour; daily; for 4 days | | Result: | Significantly restored MPTP (30 mg/kg; IP; One hour after injection) induced locomotion, dopaminergic neuronal cell death and dopamine content in DJ-1(+/+) mice but not in DJ-1(-/-) mice.
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| [References]
[1] Kazuko Takahashi-Niki, et al. DJ-1-dependent protective activity of DJ-1-binding compound no. 23 against neuronal cell death in MPTP-treated mouse model of Parkinson's disease. DOI:10.1016/j.jphs.2015.01.010 |
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