| Identification | Back Directory | [Name]
ACTH (1-17) | [CAS]
7266-47-9 | [Synonyms]
ACTH (1-17)
SYSMEHFRWGKPVGKKR
ACTH (1-17), HUMAN
ALPHA 1-17-CORTICOTROPIN
alpha1-17-ACTH
alpha1-17-Corticotropin
ADRENOCORTICOTROPIC HORMONE (1-27)
ADRENOCORTICOTROPIC HORMONE FRAGMENT 1-17
ADRENOCORTICOTROPIC HORMONE (1-17), HUMAN
ADRENOCORTICOTROPIC HORMONE HUMAN FRAGMENT 1-17
adrenocorticotropic hormone fragment*1-17 human
adrenocorticotropic hormone fragment 1-17 human, rat
Adrenocorticotropic hormone fragment 1-17 human (ACTH)
SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG
H-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-OH | [Molecular Formula]
C95H145N29O23S | [MDL Number]
MFCD00133033 | [MOL File]
7266-47-9.mol | [Molecular Weight]
2093.41 |
| Chemical Properties | Back Directory | [density ]
1.48±0.1 g/cm3(Predicted) | [RTECS ]
GM7907000 | [storage temp. ]
−20°C
| [form ]
Lyophilized powder | [Water Solubility ]
Soluble in Water | [Sequence]
Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg | [InChIKey]
MXNMAFWEFLFAJN-QBQLSIIBSA-N |
| Hazard Information | Back Directory | [Uses]
ACTH (1-17), an adrenocorticotropin analogue, is a potent human melanocortin 1 (MC1) receptor agonist with a Ki of 0.21 nM. | [Biochem/physiol Actions]
ACTH fragment with moderate adrenocorticotropic and melanocyte-stimulating activities. | [in vivo]
Inhibition of DNA labeling is noted when the ACTH (1-17) is administered at 2 hr after the beginning of the daily dark span when nocturnal animals become active. When administered at this circadian stage, the larger dose in particular is associated with an inhibition of DNA labeling lasting for 24 hr. The inhibitory effect is much shorter when the same dose is injected 4 hr earlier[3]. | [References]
[1] Tsatmali M et al. ACTH1-17 is a more potent agonist at the human MC1 receptor than alpha-MSH. Cell Mol Biol (Noisy-le-grand). 1999 Nov;45(7):1029-34. PMID:10644006
[2] Ceda GP, et al. The effects of ACTH (1-17) on GH secretion in vitro. Horm Metab Res. 1987 Aug;19(8):361-3. DOI:10.1055/s-2007-1011824
[3] Walker WV, et al. Effect of an adrenocorticotropin analogue, ACTH (1-17), on DNA synthesis in murine metaphyseal bone. Biochem Pharmacol. 1985 Apr 15;34(8):1191-6. DOI:10.1016/0006-2952(85)90494-0 |
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Sigma-Aldrich
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