ChemicalBook--->CAS DataBase List--->727721-37-1

727721-37-1

727721-37-1 Structure

727721-37-1 Structure
IdentificationBack Directory
[Name]

PT-ttpy
[CAS]

727721-37-1
[Synonyms]

PT-ttpy
[Molecular Formula]

C22H17Cl2N3Pt
[MDL Number]

MFCD32264619
[MOL File]

727721-37-1.mol
[Molecular Weight]

589.38
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

DMSO: 0.2mg/mL (warmed)
[form ]

powder
[color ]

faint yellow to dark orange
Hazard InformationBack Directory
[Uses]

Pt-ttpy, a metallo-organic complex and potent G-quadruplex ligand, effectively triggers substantial telomere-related DNA damage in cancer cells by inhibiting telomerase and/or telomere functions, while also causing various chromatin abnormalities during mitosis, such as chromatin bridges, ultrafine bridges (UFBs), and double-stranded breaks (DSBs).
[Biological Activity]

Pt-ttpya metallo-organic complexis a G-quadruplex ligand th at potently induces significant telomere-associated DNA damage in cancer cells. It inhibits telomerase and/or telomere functions. Pt-ttpy induces number of chromatin defects in mitosis including chromatin bridgesultrafine bridges (UFBs)and double-stranded breaks (DSBs).
[References]

[1] P.P. Losada et al.Fresenius Journal of Analytical Chemistry1993
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