| Hazard Information | Back Directory | [Uses]
Pt-ttpy, a metallo-organic complex and potent G-quadruplex ligand, effectively triggers substantial telomere-related DNA damage in cancer cells by inhibiting telomerase and/or telomere functions, while also causing various chromatin abnormalities during mitosis, such as chromatin bridges, ultrafine bridges (UFBs), and double-stranded breaks (DSBs). | [Biological Activity]
Pt-ttpya metallo-organic complexis a G-quadruplex ligand th at potently induces significant telomere-associated DNA damage in cancer cells. It inhibits telomerase and/or telomere functions. Pt-ttpy induces number of chromatin defects in mitosis including chromatin bridgesultrafine bridges (UFBs)and double-stranded breaks (DSBs). | [References]
[1] P.P. Losada et al.Fresenius Journal of Analytical Chemistry1993 |
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Merck KGaA
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