| Identification | Back Directory | [Name]
Oleoyl Serinol | [CAS]
72809-08-6 | [Synonyms]
Oleoyl Serinol
N-Oleoyl serinol
N-(1,3-dihydroxypropan-2-yl)oleamide
9-Octadecenamide, N-[2-hydroxy-1-(hydroxymethyl)ethyl]-, (9Z)- | [Molecular Formula]
C21H41NO3 | [MOL File]
72809-08-6.mol | [Molecular Weight]
355.56 |
| Chemical Properties | Back Directory | [Melting point ]
99-100 °C | [Boiling point ]
547.629±50.00 °C(Press: 760.00 Torr)(predicted) | [density ]
0.961±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [solubility ]
DMF: >30 mg/ml; DMSO: >15 mg/ml; Ethanol: >30 mg/ml; PBS (pH 7.2): >290 μg/ml | [form ]
A crystalline solid | [pka]
13.977±0.10(predicted) | [Cosmetics Ingredients Functions]
SKIN CONDITIONING
SKIN CONDITIONING - EMOLLIENT
SKIN PROTECTING |
| Hazard Information | Back Directory | [Uses]
N-Oleoyl serinol is a ceramide analog that can be used in stem cell therapy to prevent stem cells from developing into teratomas. N-Oleoyl serinol induces apoptosis in residual pluripotent embryoid body-derived cells (EBCs), prevents teratoma formation, and enriches EBC cells that undergo neural differentiation after transplantation[1]. | [References]
[1] Bieberich E, et al. Selective apoptosis of pluripotent mouse and human stem cells by novel ceramide analogues prevents teratoma formation and enriches for neural precursors in ES cell-derived neural transplants. J Cell Biol. 2004 Nov 22;167(4):723-34. DOI:10.1083/jcb.200405144 |
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