73326-98-4

中文名称 5氢-吡啶并[4,3-B]咔唑-5,11(6氢)-二酮

英文名称 5H-Pyrido[4,3-b]carbazole-5,11(6H)-dione

CAS 73326-98-4

分子式 C15H8N2O2

分子量 248.24

MOL 文件 73326-98-4.mol

73326-98-4 结构式

基本信息物理化学性质应用领域

基本信息

中文别名

5氢-吡啶并[4,3-B]咔唑-5,11(6氢)-二酮

英文别名

5H-Pyrido[4,3-b]carbazole-5,11(6H)-dione

所属类别

医药中间体：原料药中间体

物理化学性质

熔点>300 °C(Solv: ethyl ether (60-29-7); hexane (110-54-3))

沸点543.0±40.0 °C(Predicted)

密度1.506±0.06 g/cm3(Predicted)

酸度系数(pKa)11.81±0.20(Predicted)

形态Solid

颜色Light brown to brown

应用领域

用途一

Ellipticine quinone, also known as NSC-383230, is a Drp1 inhibitor. rpitor1 and Drpitor1a inhibited the GTPase activity of Drp1 without inhibiting the GTPase of dynamin 1. Ellipticine quinone showed greater potency than the current std. Drp1 GTPase inhibitor, mdivi-?1, (IC50 for mitochondrial fragmentation are (0.06, and 10 μM, resp.)?. Ellipticine quinone suppressed lung cancer tumor growth in a mouse xenograft model. Ellipticine quinone also inhibited mitochondrial ROS prodn., prevented mitochondrial fission, and improved right ventricular diastolic dysfunction during IR injury.