| Identification | More | [Name]
ETHYL 2-CHLOROBENZOATE | [CAS]
7335-25-3 | [Synonyms]
2-CHLOROBENZOIC ACID ETHYL ESTER
ETHYL 2-CHLOROBENZOATE
ETHYL O-CHLOROBENZOATE
O-CHLOROBENZOIC ACID ETHYL ESTER
RARECHEM AL BI 0018
ETHYL 2-CHLOROBENZOATE 98%
Ethyl 2-chlorobenzoate, 98+% | [EINECS(EC#)]
230-842-6 | [Molecular Formula]
C9H9ClO2 | [MDL Number]
MFCD00016338 | [Molecular Weight]
184.62 | [MOL File]
7335-25-3.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [TSCA ]
TSCA listed | [HS Code ]
29163990 |
| Hazard Information | Back Directory | [Chemical Properties]
Clear colorless to pale yellow liquid | [Synthesis]
GENERAL PROCEDURE: In a dry Schlenk tube, sodium hydride (6.0 mmol) was stirred with ethyl trifluoroacetate (6.0 mmol) in tetrahydrofuran (5 mL) for 10 minutes at room temperature under argon protection. Subsequently, a solution of enolizable ketone (5.0 mmol) in tetrahydrofuran (5 mL) was slowly added dropwise to the above mixture at 0°C and under argon atmosphere. The reaction solution was stirred at a set temperature for 2 to 6 hours before being cooled again to 0°C and the reaction was quenched with 6 mL of a 1 mol/L hydrochloric acid solution. After continued stirring for 15 minutes, the mixture was neutralized with saturated sodium bicarbonate solution. After conventional post-treatment steps, the residue was purified by silica gel column chromatography to give the target product trifluoromethyl alkyl ketone. | [References]
[1] Tetrahedron, 2014, vol. 70, # 31, p. 4668 - 4674 |
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