| Identification | Back Directory | [Name]
hamaudol | [CAS]
735-46-6 | [Synonyms]
hamaudol
(S)-3,4-Dihydro-3β,5-dihydroxy-2,2,8-trimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one
2H,6H-Benzo[1,2-b:5,4-b']dipyran-6-one, 3,4-dihydro-3,5-dihydroxy-2,2,8-trimethyl-, (3S)- | [Molecular Formula]
C15H16O5 | [MDL Number]
MFCD32220467 | [MOL File]
735-46-6.mol | [Molecular Weight]
276.28 |
| Chemical Properties | Back Directory | [Melting point ]
197.0-197.5 °C | [Boiling point ]
464.7±45.0 °C(Predicted) | [density ]
1.336±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
6.77±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Hamaudol is a chromone isolated from Saposhnikovia divaricata. Hamaudol shows significant inhibitory activity on cyclooxygenase (COX)-1 and COX-2 activities with IC50 values of 0.30, 0.57 mM, respectively, and has potent analgesia and anti-inflammary effects[1][2]. | [Definition]
ChEBI: Hamaudol is a member of chromenes. | [Biological Activity]
Hamaudol is a chromone isolated from Saposhnikovia divaricata. It has obvious inhibitory ability on the activities of cyclooxygenase (COX)-1 and COX-2 with IC50 values of 0.30 and 0.57 mM, respectively, and has potent analgesic and anti-inflammatory effects. | [in vivo]
Hamaudol (Compound 7) increases the potency to exhibit a potent analgesia at doses of 1, 5 and 10 mg/kg in mice, although it do not show clear dose dependency. < b> | [target]
| COX-1 < span> 0.3 mM (IC 50 ) | COX-2 0.57 mM (IC 50 ) | | [IC 50]
COX-1: 0.3 mM (IC50); COX-2: 0.57 mM (IC50) | [storage]
Store at -20°C | [References]
[1] Okuyama E, et al. Analgesic components of saposhnikovia root (Saposhnikovia divaricata). Chem Pharm Bull (Tokyo). 2001 Feb;49(2):154-60. DOI:10.1248/cpb.49.154
[2] Mingshan Zheng, et al. The Constituents Isolated from Peucedanum japonicum Thunb. and their Cyclooxygenase (COX) Inhibitory Activity. Korean Journal of Medicinal Crop Science, 2005, 13(2). |
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