| Identification | Back Directory | [Name]
CIMIFUGIN BETA-D-GLUCOPYRANOSIDE | [CAS]
80681-45-4 | [Synonyms]
Cimifugin 7-glucoside
rim-O-glucosylcimifugin
prim-O-Glucosylcimifugin
CIMIFUGIN BETA-D-GLUCOPYRANOSIDE
5H-Furo[3,2-g][1]benzopyran-5-one,7-[(β-D-
CIMIFUGIN BETA-D-GLUCOPYRANOSIDE USP/EP/BP
Prim-O-glucosylcimifugin, 98%, from Cimicifuga foetida L.
glucopyranosyloxy)methyl]-2,3-dihydro-2-(1-hydroxy-1-methylethyl)-4-methoxy-,(2S)-
5H-Furo[3,2-g][1]benzopyran-5-one, 7-[(β-D-glucopyranosyloxy)methyl]-2,3-dihydro-2-(1-hydroxy-1-methylethyl)-4-methoxy-, (2S)-
(2S)-2-(2-hydroxypropan-2-yl)-4-methoxy-7-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-2,3-dihydrofuro[3,2-g]chromen-5-one | [Molecular Formula]
C22H28O11 | [MDL Number]
MFCD09037394 | [MOL File]
80681-45-4.mol | [Molecular Weight]
468.452 |
| Chemical Properties | Back Directory | [Melting point ]
118～120℃ | [Boiling point ]
736.9±60.0 °C(Predicted) | [density ]
1.53±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMF: 15 mg/ml; DMSO: 15 mg/ml; Ethanol: 15 mg/ml; PBS (pH 7.2): 5 mg/ml | [form ]
powder to crystal | [pka]
12.94±0.70(Predicted) | [color ]
White to Light yellow | [InChIKey]
XIUVHOSBSDYXRG-BZOGYWBENA-N | [SMILES]
C12=C(C=C3O[C@H](C(C)(C)O)CC3=C1OC)OC(CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)=CC2=O |&1:5,19,21,24,26,28,r| |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in methanol, derived from Fangji, Fangfeng, Huashan Qianhu. | [Uses]
Prim-O-glucosylcimifugin have anti-inflammatory, immunosuppressive effects. | [Definition]
ChEBI: PRIM-O-GLUCOSYLCIMIFUGIN is an organic heterotricyclic compound and an oxacycle. | [in vivo]
Bronchoalveolar lavage fluid (BALF) is collected at 7 h after lipopolysaccharide (LPS) administration and the
cytokine levels in BALF are measured by ELISA. The levels of TNF-α, IL-1β and IL-6 in BALF are increased dramatically compared with control group. However, pretreatment with Prime-O-glucosylcimifugin (2.5, 5 or 10 mg/kg) significantly down-regulates the levels of TNF-α, IL-1β and IL-6 in a dose-dependent manner (P<0.05, P<0.01)[1]. | [target]
| [IC 50]
iNOS; COX-2 | [storage]
4°C, protect from light |
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