| Identification | Back Directory | [Name]
Fmoc-Thr-Obzl | [CAS]
73724-48-8 | [Synonyms]
Fmoc-Thr-OBN
FMoc-Thr-obzl
Fmoc-L-Thr-OBzl
FMOC-L-THR(BZL)-OH
FMOC-THREONINE(BZL)-OH
N-A-FMOC-O-BENZYL-L-THREONINE
N-ALPHA-FMOC-O-BENZYL-L-THREONINE
N-(9-Fluorenylmethoxycarbonyl)threonine benzyl ester
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-BENZYL-L-THREONINE
N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-O-BENZYL-L-THREONINE
N-ALPHA-(9-FLUOROENYLMETHYLOXYCARBONYL)-O-BENZYL-L-THREONINE
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-threonine phenylmethyl ester
L-Threonine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, phenylmethyl ester
benzyl (2S,3R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-hydroxybutanoate
(2S,3R)-Benzyl 2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-hydroxybutanoate | [Molecular Formula]
C26H25NO5 | [MDL Number]
MFCD11505901 | [MOL File]
73724-48-8.mol | [Molecular Weight]
431.48 |
| Chemical Properties | Back Directory | [Boiling point ]
656.9±55.0 °C(Predicted) | [density ]
1.257±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [pka]
10.34±0.46(Predicted) | [Appearance]
White to off-white Solid | [InChIKey]
WQYIETDVEJEHCP-OSPHWJPCSA-N | [SMILES]
C(OCC1=CC=CC=C1)(=O)[C@H]([C@H](O)C)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O |
| Hazard Information | Back Directory | [Synthesis]
Fmoc(OTIPS) benzyl ester (0.87 g, 1.48 mmol) is dissolved in 7.4 mL dry CH2Cl2 under an argon atmosphere. The solution is cooled to 0°C and 7.4 mL of 40% (v/v) Piperidine solution in dry CH2Cl2 is added dropwise. After 15 min of stirring at 0°C, the mixture is concentrated in vacuo at 25°C to an oil and put immediately onto the silica column (cyclohexane/EtOAc 5: 1 + 0.5% NEt3, elution of product with 1: 1 + 0.5% NEt3). The yield of Fmoc-Thr-Obzl is 0.44 g (1.20 mmol, 81%) as a colorless oil.
| [References]
[1] Tetrahedron, 2012, vol. 68, # 2, p. 697 - 704
[2] Organic and Biomolecular Chemistry, 2007, vol. 5, # 16, p. 2645 - 2657
[3] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 1, p. 145 - 156
[4] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 7, p. 1978 - 1987
[5] ChemBioChem, 2017, vol. 18, # 6, p. 527 - 538 |
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| Company Name: |
Shanghai GL Peptide Ltd.
|
| Tel: |
+86-21-61263340; 17609490614 13764994101 |
| Website: |
https://www.chemicalbook.com/supplier/10480342/ |
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