| Identification | Back Directory | [Name]
4-(2-(Pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline | [CAS]
737791-20-7 | [Synonyms]
4-(2-(Pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline
Quinoline, 4-[5,6-dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]- | [Molecular Formula]
C20H16N4 | [MDL Number]
MFCD27920504 | [MOL File]
737791-20-7.mol | [Molecular Weight]
312.37 |
| Hazard Information | Back Directory | [Uses]
LY550410 is a small-molecule ATP-competitive inhibitor against type I TGF-β receptor kinase, which contains heteroaryl rings for potent binding to the kinase-domain active site. LY550410 modulates TGF-β signalling, thereby regulates gene expression and ultimately cell growth. LY550410 is promising for research of cancers[1]. | [References]
[1] Yingling JM, et al. Development of TGF-beta signalling inhibitors for cancer therapy. Nat Rev Drug Discov. 2004 Dec;3(12):1011-22. DOI:10.1038/nrd1580 |
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