| Identification | Back Directory | [Name]
2-Methylpyrazolo[1,5-a]pyriMidine-6-carboxylic acid | [CAS]
739364-95-5 | [Synonyms]
2-Methylpyrazolo[1
Anagliptin InterMediate A
2-Methylpyrazolo[1,5-a]py...
5-a]pyriMidine-6-carboxylic acid
2-Methylpyrazolo[1,5-a]pyriMidine-6-carboxylic acid
2-Methylpyraolo[1,5-
a]pyriMidine-6-carboxylic acid
Pyrazolo[1,5-a]pyrimidine-6-carboxylic acid, 2-methyl-
2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid 95+%
2-Methylpyrazolo[1,5-A]pyrimidine-6-carboxylic acid(PPCA)
L-tert-leucine 2-Methyl-pyrazolo(1,5-a)pyriMidine-6-carboxylic acid
2-Methylpyrazolo[1,5-a]pyriMidine-6-carboxylic acid [(2-Methylpyrazolo[1 | [EINECS(EC#)]
1308068-626-2 | [Molecular Formula]
C8H7N3O2 | [MDL Number]
MFCD19443280 | [MOL File]
739364-95-5.mol | [Molecular Weight]
177.16 |
| Chemical Properties | Back Directory | [Melting point ]
238 °C(dec.) | [density ]
1.49±0.1 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
-0.17±0.41(Predicted) | [color ]
White to Off-White | [InChI]
InChI=1S/C8H7N3O2/c1-5-2-7-9-3-6(8(12)13)4-11(7)10-5/h2-4H,1H3,(H,12,13) | [InChIKey]
YHVGUXFUOSJCFJ-UHFFFAOYSA-N | [SMILES]
C12=CC(C)=NN1C=C(C(O)=O)C=N2 |
| Hazard Information | Back Directory | [Uses]
2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic Acid is a reactant used in the preparation of DPP-IV inhibitors. | [Synthesis]
The general procedure for the synthesis of 2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid, using the compound (CAS: 338953-49-4) as a starting material, was as follows (Intermediate Example 16): 2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid amide (475 mg) was dissolved in ethanol (5 mL), and a 5 N sodium hydroxide solution was subsequently added to the solution (2 mL). The reaction mixture was stirred at 70 °C for 1 hour. After completion of the reaction, the mixture was cooled to room temperature, an appropriate amount of water was added and the reaction mixture was washed with ethyl acetate. After separating the aqueous phase, 2 N hydrochloric acid was added dropwise until the pH became acidic. The precipitated white crystals were collected by filtration and washed sequentially with water and hexane. Finally, the resulting crystals were dried under reduced pressure to afford the target product 2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid (300 mg, yield: 63%). Product mass spectral data: ESI/MS m/z 178 ([M+H]+), 176 ([M-H]-). | [References]
[1] Patent: EP1595866, 2005, A1. Location in patent: Page/Page column 13
[2] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 23, p. 7221 - 7227 |
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