| Identification | More | [Name]
N,N'-Disuccinimidyl carbonate | [CAS]
74124-79-1 | [Synonyms]
2,5-PYRROLIDINEDIONE, 1,1'-[CARBONYLBIS(OXY)]BIS-
BIS(N-SUCCINIMIDYL) CARBONATE
DI-(N,N'-SUCCINIMIDYL) CARBONATE
DI(N-SUCCINIMIDYL) CARBONATE
DI(SUCCINIMIDO) CARBONATE
DISUCCINIMIDYL CARBONATE
DSC
LABOTEST-BB LT00847311
N,N'-DISUCCINIMIDYL CARBONATE
N-SUCCINIMIDYL CARBONATE
SU2O
(SUO)2CO
TIMTEC-BB SBB005976
N,N'-DISUCCINIMIDYL CARBONATE, TECH.
DSC [N,N'-DISUCCINIMIDYL CARBONATE]
N,N'-Disuccinimidyl carbonate (DSC)
N,N'-DisuccinimidylCarbonate98%
N,N'-Disuccinimido Carbonate
DSCsee24500
N,N'-Disuccinimidyl | [EINECS(EC#)]
277-730-3 | [Molecular Formula]
C9H10N2O7 | [MDL Number]
MFCD00009767 | [Molecular Weight]
258.18 | [MOL File]
74124-79-1.mol |
| Chemical Properties | Back Directory | [Appearance]
white to slightly yellow crystalline powder | [Melting point ]
190 °C (dec.)(lit.) | [Boiling point ]
399.41°C (rough estimate) | [density ]
1.5670 (rough estimate) | [refractive index ]
1.5600 (estimate) | [storage temp. ]
2-8°C
| [solubility ]
Dichloromethane (Slightly, Heated), DMSO | [form ]
Crystalline Powder | [color ]
White to slightly yellow | [Water Solubility ]
Soluble in dimethyl sulfoxide, hot pyridine, acetonitrile and most organic solvents. Insoluble in water. | [Detection Methods]
HPLC,NMR | [BRN ]
1499137 | [Stability:]
Moisture Sensitive | [InChI]
InChI=1S/C9H8N2O7/c12-5-1-2-6(13)10(5)17-9(16)18-11-7(14)3-4-8(11)15/h1-4H2 | [InChIKey]
PFYXSUNOLOJMDX-UHFFFAOYSA-N | [SMILES]
C(ON1C(=O)CCC1=O)(=O)ON1C(=O)CCC1=O | [CAS DataBase Reference]
74124-79-1(CAS DataBase Reference) | [Storage Precautions]
Moisture sensitive;Store under nitrogen |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [F ]
10-21 | [TSCA ]
No | [HS Code ]
29299000 |
| Hazard Information | Back Directory | [Chemical Properties]
N,N'-Disuccinimidyl carbonate is white to slightly yellow crystalline powder
| [Uses]
N,N'-Disuccinimidyl carbonate is a convenient reagent for the synthesis of N-succinimidyl esters of N-protected amino acids.
| [Uses]
N,N’Disuccinimidyl Carbonate is a commonly used reagent for the preparation of N-succinimidyl esters of N-protected amino acids, activated carbonate, synthesis of urea, carbamates and coupling of lig ands to proteins. The coupling reagent property of N,N’Disuucinimidyl Carbonate speeds up coupling process, while reduces the loss of chiral integrity.
| [Uses]
N,N'-Disuccinimidyl carbonate is used to prepare cleavable linker succinimide vinylsufonylethyl carbonate for thiol modified-DNA. It serves as a reagent for the synthesis of carbamates. Further, it is used as a coupling reagent as well as in the preparation of N-succinimidyl esters of N-protected amino acids, activated carbonate and coupling of ligand to proteins. | [Synthesis Reference(s)]
Tetrahedron Letters, 20, p. 4745, 1979 DOI: 10.1016/S0040-4039(01)86699-5 | [General Description]
N,N′-Disuccinimidyl carbonate is used for the HPLC determination of amino compounds. | [reaction suitability]
reaction type: Coupling Reactions |
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