| Identification | Back Directory | [Name]
1-azido-2-[2-(2-methoxyethoxy)ethoxy]ethane | [CAS]
74654-06-1 | [Synonyms]
mPEG3-Azide
azido-mPEG3
N3-PEG3-O-ME
1-Azido-3,6,9-trioxadecane
2-(2-(2-methoxyethoxy)ethoxy)ethyl azide
1-azido-2-[2-(2-methoxyethoxy)ethoxy]ethane
Ethane, 1-(2-azidoethoxy)-2-(2-methoxyethoxy)- | [Molecular Formula]
C7H15N3O3 | [MDL Number]
MFCD22574767 | [MOL File]
74654-06-1.mol | [Molecular Weight]
189.212 |
| Chemical Properties | Back Directory | [Boiling point ]
58 °C(Press: 0.01 Torr) | [density ]
1.08 g/mL | [refractive index ]
n/D 1.4472 | [storage temp. ]
2-8°C | [form ]
liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
m-PEG3-azide is a PEG linker containing an azide group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
m-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [reaction suitability]
reaction type: click chemistry | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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