| Identification | Back Directory | [Name]
Quinoxaline, 6-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]- | [CAS]
746667-48-1 | [Synonyms]
AJ-97166
BIO-013077-01
Quinoxaline(AJ-97166)
BIO-013077-01;QUINOXALINE
6-(3-(6-METHYLPYRIDIN-2-YL)-1H-PYRAZOL-4-YL)
6-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoxaline
6-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)quinoxaline
Quinoxaline, 6-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-
inhibit,Alkylation,Transforming growth factor beta receptors,BIO 013077 01,autophosphorylation,Inhibitor,fibrosis,pyrazoles,ALK5,BIO01307701,TGF-β Receptor | [Molecular Formula]
C17H13N5 | [MOL File]
746667-48-1.mol | [Molecular Weight]
287.32 |
| Chemical Properties | Back Directory | [Melting point ]
105.4 °C | [Boiling point ]
490.8±45.0 °C(Predicted) | [density ]
1.296±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO : 100 mg/mL (348.04 mM; Need ultrasonic) | [form ]
Solid | [pka]
10.05±0.50(Predicted) | [color ]
Light yellow to brown |
| Hazard Information | Back Directory | [Uses]
BIO-013077-01 is a pyrazole TGF-β inhibitor[1]. | [References]
[1] Jin CH, et al. Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors. Eur J Med Chem. 2011 Sep;46(9):3917-25. DOI:10.1016/j.ejmech.2011.05.063 |
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