| Identification | Back Directory | [Name]
(3R)-2,3-Dihydro-5,7-dihydroxy-3-[(4-methoxyphenyl)methyl]-6,8-dimethyl-4H-1-benzopyran-4-one | [CAS]
74805-91-7 | [Synonyms]
NE-IV
Methylophiopogonanone B
R-Methylophiopogonanone B
8-Methylophiopogonanone B
Methylophiopogonanone B(R-Methylophiopogonanone B)
3-(4'-methoxy-benzyl)-5,7-dihydroxy-6,8-dimethyl-chroman-4-one
(3R)-5,7-Dihydroxy-3-(4-methoxybenzyl)-6,8-dimethyl-2,3-dihydro-4 H-chromen-4-one
(3R)-2,3-Dihydro-5,7-dihydroxy-3-[(4-methoxyphenyl)methyl]-6,8-dimethyl-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-3-[(4-methoxyphenyl)methyl]-6,8-dimethyl-, (3R)- | [Molecular Formula]
C19H20O5 | [MDL Number]
MFCD20487835 | [MOL File]
74805-91-7.mol | [Molecular Weight]
328.359 |
| Chemical Properties | Back Directory | [Boiling point ]
554.5±49.0 °C(Predicted) | [density ]
1.285 | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
Soluble in acetone, chloroform and methanol; | [form ]
powder | [pka]
8.24±0.40(Predicted) | [color ]
Light yellow | [Water Solubility ]
insoluble in water |
| Hazard Information | Back Directory | [Description]
Methylophiopogonanone B (MO‑B), which belongs to a group of homoisoflavonoids, present in Ophiopogon japonicus, has been identified as an active component with antioxidative and anti‑tumor properties.
| [Chemical Properties]
Methylophiopogonanone B is soluble in methanol, ethanol, DMSO and other organic solvents, and is derived from the fibrous root of Ophiopogon japonicus. | [Uses]
Methylophiopogonanone B has the effect of enhancing protease activity and regulating cytoskeleton remodeling. | [Synthesis]
Methylophiopogonanone B was synthesized from 2,4,6-trihydroxy-3,5-dimethylacetophenone in 57% yield.
| [References]
[1] M. FUJII. First synthesis of racemic methylophiopogonanone B and its inhibitory activity of hypoxia-inducible factor-1α[J]. Heterocycles, 2009, 78 1: 207-212. DOI:10.3987/COM-08-11517. |
|
|